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ISSN: 2637-6628

Online Journal of Neurology and Brain Disorders

Research Article(ISSN: 2637-6628)

Progresses in Gene Therapy of Neurodegenerative Disorders

Volume 1 - Issue 1

Ashim Kumar Basak and Tridip Chatterjee*

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    • Department of Molecular Biology, Institute of Genetic Engineering, India

    *Corresponding author: Tridip Chatterjee, Department of Molecular Biology, Institute of Genetic Engineering, India

Received: January 25, 2018;   Published: February 15, 2018

DOI: 10.32474/OJNBD.2018.01.000103

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Abstract

Gene therapy is a technique that uses genes to treat or prevent diseases. Gene therapy to the brain faces other difficulties in addition to the general issues one faces with gene therapy. A major limiting factor for the delivery of gene to the brain is the blood brain barrier (BBB), which most gene expression vectors can not cross naturally. However, recent advances in gene transfer technology have led to promises for delivery of therapeutic genes to brain. In this small review we shall make a discussion on the recent developments of gene therapies for some important neurodegenerative disorders.

Keywords: Gene therapy; Viral vectors; Alzheimer’s disease; Parkinson’s disease; Huntington disease; Canavan disease; X-Linked adrenoleukodystrophy.

Abstract| Introduction| Discussion| References|

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