Progresses in Gene Therapy of Neurodegenerative
Disorders
Volume 1 - Issue 1
Ashim Kumar Basak and Tridip Chatterjee*
-
Author Information
Open or Close
- Department of Molecular Biology, Institute of Genetic Engineering, India
*Corresponding author:
Tridip Chatterjee, Department of Molecular Biology, Institute of Genetic Engineering, India
Received: January 25, 2018; Published: February 15, 2018
DOI: 10.32474/OJNBD.2018.01.000103
Full Text
PDF
To view the Full Article Peer-reviewed Article PDF
Abstract
Gene therapy is a technique that uses genes to treat or prevent diseases. Gene therapy to the brain faces other difficulties
in addition to the general issues one faces with gene therapy. A major limiting factor for the delivery of gene to the brain is the
blood brain barrier (BBB), which most gene expression vectors can not cross naturally. However, recent advances in gene transfer
technology have led to promises for delivery of therapeutic genes to brain. In this small review we shall make a discussion on the
recent developments of gene therapies for some important neurodegenerative disorders.
Keywords: Gene therapy; Viral vectors; Alzheimer’s disease; Parkinson’s disease; Huntington disease; Canavan disease; X-Linked
adrenoleukodystrophy.
Abstract|
Introduction|
Discussion|
References|