mTOR Signaling and Drug Memory
Volume 5 - Issue 2
Shihao Huang and Yixiao Luo*
- Key Laboratory of Molecular Epidemiology of Hunan Province, School of Medicine, Hunan Normal University, Changsha, China
Received: February 08, 2021 Published:February 16, 2021
Corresponding author: Yixiao Luo, Key Laboratory of Molecular Epidemiology of Hunan Province, School of Medicine, Hunan Normal University, Changsha, China
DOI: 10.32474/OJNBD.2021.05.000207
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Abstract
Drug addiction is a chronic, relapsing brain disorder. Pathological neuroplasticity changes in the brain areas involved in cognition, memory and reward lead to intensely psychological dependence on abused drugs in addicts. The key to drug addiction treatment is how to prevent the high relapse rate after withdrawal. Mammalian Target of Rapamycin (mTOR) signaling pathway exists widely in vivo and has variously complex physiological function, which can regulate drug memory by affecting synaptic plasticity. This mini-review discussed the role and research progress of the mTOR signaling pathway in drug memory.
Introduction|
Drug memory and relapse|
mTOR Signaling|
mTOR Signaling and Drug Memory|
Conclusion and Future Direction|
References|