Fibrinogen and/or Fibrin as a Cause of Neuroinflammation Volume 5 - Issue 4

Nurul Sulimai¹ and David Lominadze²*

• ¹Department of Surgery, University of South Florida Morsani College of Medicine, USA
• ²Department of Molecular Pharmacology and Physiology, University of South Florida Morsani College of Medicine, USA

Received:April 6, 2021   Published:April 14, 2021

Corresponding author: David Lominadze, Department of Surgery, USF Health-Morsani College of Medicine, USA

DOI: 10.32474/OJNBD.2021.05.000217

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Involvement of fibrinogen(Fg) and fibrin during various pathologies associated with neuroinflammatory diseases associated with memory reduction are well known. Elevated level of Fg, called hyperfibrinogenemia (HFg) (e.g. ≥ 4±0.1 mg/ml of plasma during inflammation vs.~2±0.1 mg/ml of normal plasma [1]), accompanies inflammatory diseases such as stroke [2,3], hypertension [1,4], diabetes [5] and traumatic brain injury (TBI) [6-9]. Blood level of Fg increases during inflammation in general [10]. HFg is considered not only a marker of inflammation [11] but also a cause of inflammatory responses [12-16]. Gradual extravascular deposition of Fg in the brain accelerates neurovascular damage and promotes neuroinflammation [17,18]. It has been shown that Fg is associated with an increased risk of dementia and AD [19]. Derivative of Fg, fibrin have been found postmortem in the brains of patients with TBI [18,20,8], Alzheimer’s Disease (AD) [21], and multiple sclerosis (MS) [22]

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