Aseptic Meningitis Revealing Isolated Kikuchi-
Fujimoto Disease
Volume 2 - Issue 1
Salem Bouomrani* and Nesrine Regaïeg
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- Department of Internal medicine, Sfax Faculty of Medicine, Tunisia
*Corresponding author:
Salem Bouomrani, Department of Internal medicine, Military Hospital of Gabes, Gabes 6000. Tunisia
Received: November 02, 2018; Published: November 08, 2018;
DOI: 10.32474/OJNBD.2018.01.000129
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Abstract
Introduction: Kikuchi-Fujimoto’s disease (KFD) or histiocytic necrotizing lymphadenitis is a rare entity that may represent a
real diagnostic challenge for the clinician because of its highly polymorphous and sometimes unusual presentations. We report an
original observation of KFD with aseptic meningitis as inaugural manifestation.
Case report: 30-year-old woman, without pathological medical history, was hospitalized via the emergency department for
exploration of a meningeal syndrome with cervical lymphadenopathies. The lumbar puncture showed aseptic meningitis: clear,
normotensive cerebrospinal fluid with leukocytes at 28/mm3 (90% lymphocytes), red blood cells at 2/mm3, proteinrrhachia at 0.58
g/l, glucorrachia at 4 mmol/l for venous glycemia at 8 mmol/l, and negative direct examination and culture. Cerebromedullary MRI
and cerebral angio-MR were without abnormalities. Further infectious and immunological investigations were negative. Cervical
lymph node biopsy showed histological and Immunohistochemical aspects suggesting KFD. Treated with systemic corticosteroids,
the evolution was favorable with no recurrence.
Conclusion: KFD-associated aseptic meningitis remains rare, and the inaugural forms are exceptional and often difficult to
diagnose. A better knowledge of this association avoids unnecessary investigations, recurrence, and improves the prognosis of the
disease.
Keywords: Aseptic Meningitis; Kikuchi–Fujimoto’s Disease; Histiocytic Necrotizing Lymphadenitis
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