Post-Breast Cancer Chronic Wounds with Solid Calcifications Treated with Cu/SiO₂-TiO₂ Nano Biocatalyst

Volume 3 - Issue 3

Tessy López*^1,2, Verónica Sánchez de la Barquera³, Francisco J Padilla-Godínez¹, Paola Ramírez¹ and Esteban Gómez-López⁴

Received: October 03, 2020;   Published: October 22, 2020

DOI: 10.32474/MAMS.2020.03.000163

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Abstract

Objective: To describe patient outcomes with respect to the use of Cu/SiO₂-TiO₂ nanoparticles embedded in a polymeric gel as treatment for post-breast cancer chronic wounds with solid calcifications.

Methods: The nanoparticles were synthesized by the sol-gel method. The compound was incorporated into a polymeric gel matrix. SEM and TEM microscopy studies were carried out to evaluate grain size, morphology, and texture of the pure nanoparticles. The chronic wounds were treated by applying zinc oxide as emollient, Triticum vulgare (Italdermol®) and the Nano biocatalyst. The wound was covered with Solvaline® N dressings for the absorption of the exudate.

Results: The Cu/SiO₂-TiO₂ nanobiocatalyst displayed average particle size between 5 and 10 nm with high particle dispersion. Ordered arrangement of the nanoparticles was observed in TEM micrographs suggesting anatase crystalline structure. Microcalcifications extracted from the wound were suspected to be calcium carbonates and calcium oxalates, exhibiting sizes of the order of 20 μm. The administration of the nanoparticles with Triticum vulgare enhanced granulation tissue formation and revascularization by limiting bacterial infection. After 8 months of the first application the wound had completely healed in an atrophic scar, with no sign of inflammation or infection. No adverse effects were observed in the patient.

Conclusions: Post-breast cancer chronic wounds were successfully treated with Cu/SiO₂-TiO₂ nanoparticles. Good outcomes were observed in terms of tissue regeneration, wound healing, and infection hindering. Calcifications were eliminated. The nanoparticles can be used as a primary apposite to stimulate the autolytic debridement of injures due to their excellent local absorption and bactericide action.

Declaration of Interest: The study’s sponsors were not involved in the study design, the collection, analysis and interpretation of the data, the writing of this manuscript and the decision to submit this article for publication. The views express in this article are those of the authors.

Keywords: Cu/SiO₂-TiO₂, Chronic wounds, Breast cancer, Microcalcification, Tissue regeneration

Key Points:

a. A nanobiocatalyst based on mixed-oxides impregnated with transition metals was synthesized by the sol-gel method for the treatment of a post-breast cancer chronic wound.
b. The nanobiocatalyst presented displayed average particle size between 5 and 10 nm with high particle dispersion and ordered particle arrangement suggesting anatase crystalline structure as observed by SEM and TEM.
c. The post-breast cancer wound exhibited the formation of microcalcifications (20 μm) composed of calcium carbonates and calcium oxalates.
d. The administration of the nanobiocatalyst enhanced the formation of granulation tissue and revascularization by limiting bacterial infection.
e. The 30-years-old wound completely healed in an 8-months period, with no adverse effects detected.
f. The microcalcification formation was eliminated after tissue regeneration.

Abstract| Introduction| Aim of the Study| Materials and Methods| Clinical Study| Clinical Diagnosis| Results| Discussion| Conclusion| Reflective questions| Author Contribution| Funding| Compliance With Ethical Standards| ORCID ID| References|