ICSI Clinical Outcomes in Correlation to Supplementation of Vitamin D Agent

Volume 3 - Issue 4

Amal Elshabrawy Elsayed*

Received:August 06, 2019;   Published: August 12, 2019

DOI: 10.32474/IGWHC.2018.03.000169

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Abstract

Background: With increased desires among both patients and physicians all over the world to get the optimum rates of success from ART management protocols, vitamin D is considered one of the crucial and demanding areas of research efforts that requires clarification of its exact role on various fertility aspects.

Aim: to investigate whether vitamin D supplementation enhances ICSI outcomes in cases with vitamin D deficiency without clinical symptoms.

Methodology: A clinical research study 150 females cases having an age range of 18 to 38 years having serum Vitamin D level under 30ng/ml without symptoms of Vitamin D deficiency were recruited in the research study categorized into two research groups equally numbered placebo and vitamin D research group.

Results: Statistical comparative analysis of ICSI outcomes in Vitamin D and placebo research groups in which there was no statistical significant difference as regards number of oocyte, mean ± SD, Fertilization rate (%), Number of embryos, mean ± SD, good quality embryos (%) (p values=0.489, 0.860, 0.212, 0.405 consecutively), however there was statistically highly significant difference as regards endometrial grade (p value=0.001), besides statistically higher rates of chemical and clinical pregnancies among vitamin D research group cases in comparison to placebo research group (p values=0.002, 0.019 consecutively).

Conclusion: Vitamin D supplementation has a positive impact on pregnancy rates and endometrial lining thickness in ICSI practice however future research efforts should be multicentric in fashion taking in consideration racial and ethnic differences besides BMI as a variable that could affect the vitamin D status.

Keywords: Vitamin D; ICSI; ART

Abstract| Introduction| Aim of the Work| Methodology| Results| Discussion| Conclusion and Recommendations| References|