Background: With increased desires among both patients and physicians all over the world to get the optimum rates of success
from ART management protocols, vitamin D is considered one of the crucial and demanding areas of research efforts that requires
clarification of its exact role on various fertility aspects.
Aim: to investigate whether vitamin D supplementation enhances ICSI outcomes in cases with vitamin D deficiency without
Methodology: A clinical research study 150 females cases having an age range of 18 to 38 years having serum Vitamin D level
under 30ng/ml without symptoms of Vitamin D deficiency were recruited in the research study categorized into two research
groups equally numbered placebo and vitamin D research group.
Results: Statistical comparative analysis of ICSI outcomes in Vitamin D and placebo research groups in which there was no
statistical significant difference as regards number of oocyte, mean ± SD, Fertilization rate (%), Number of embryos, mean ± SD,
good quality embryos (%) (p values=0.489, 0.860, 0.212, 0.405 consecutively), however there was statistically highly significant
difference as regards endometrial grade (p value=0.001), besides statistically higher rates of chemical and clinical pregnancies
among vitamin D research group cases in comparison to placebo research group (p values=0.002, 0.019 consecutively).
Conclusion: Vitamin D supplementation has a positive impact on pregnancy rates and endometrial lining thickness in ICSI
practice however future research efforts should be multicentric in fashion taking in consideration racial and ethnic differences
besides BMI as a variable that could affect the vitamin D status.