Background: Preterm premature rupture of membranes is a chief clinical scenario in obstetrics causing morbidity and mortality
issues at maternal and fetal levels.
Aim: To investigate the correlation and linkage between fetal urinary production rate measured by sonography, and adverse
neonatal clinical outcomes in cases with preterm premature rupture of membranes.
Methodology: A prospective observational clinical research trial of cases that are singleton gestations diagnosed having
PPROM from 24+0 to 34+6 gestational weeks, from January 2016 and March 2019. Gestational age determination was made using
the last menstrual period and verified by first trimester sonography. exclusive research criteria were as follows cases that had
spontaneous delivery within 48 hours of PPROM, other gestational medical complications (e.g. DM, hypertension), and cases having
fetal congenital malformations PPROM diagnosis have been performed using sterile speculum examination and pH assessment of
fluid obtained from the posterior vaginal fornix.
Results: The statistical correlation between adverse neonatal outcome and fetal urinary production rate, adjusted for gestational
age comparing between FUPR in neonates with adverse outcome and FUPR in neonates without adverse outcome in which there
was no statistical significant difference between both research categorical groups as regards reduced urine output in first 24 hours,
Positive cultures (urine, blood, CSF), Early sepsis (p values =0.196, 0.673, 0.192 consecutively) whereas NEC or IVH occurrence
and requirement for Blood products transfusion was statistically significantly different between FUPR in neonates with adverse
outcome and FUPR in neonates without adverse outcome (p value= 0.001, 0.006 consecutively).
Conclusion: The current study findings reveal that the determination of fetal urinary production rate is one of the cornerstone
tools that could be used to predict the arousal of adverse clinical events at maternal and perinatal levels in preterm premature
rupture of membranes. Combined with other tools also not overlooking other pathological tests including c-reactive proteins,