email   Email Us: phone   Call Us: +1 (914) 407-6109   57 West 57th Street, 3rd floor, New York - NY 10019, USA

Lupine Publishers Group

Lupine Publishers

  Submit Manuscript

ISSN: 2637-4544

Interventions in Gynaecology and Women's Healthcare

Research Article(ISSN: 2637-4544)

Evaluation of Gasometric Behavior of Transfused Fetuses in Alloimmunized Pregnant Women According to the Concentration of Circulating Adult Hemoglobin

Volume 1 - Issue 4

Naeme Jose de Sa Filho1* and Alamanda Kfoury Pereira2

  • Author Information Open or Close
    • 1Master Student, Women’s Health Postgraduate Program, Federal University of Minas Gerais
    • 2Department of Obstetrics and Gynecology, Federal University of Minas Gerais

    *Corresponding author: Naeme José de Sá Filho, Departament of Obstetrics and Gynecology, Federal University of Minas Gerais, Av. Prof. Alfredo Balena, 190 - sala 213, Belo Horizonte - MG ZIP CODE 29043-900

Received: February 02, 2018;   Published: February 21, 2018

DOI: 10.32474/IGWHC.2018.01.000116

Full Text PDF

To view the Full Article   Peer-reviewed Article PDF


Introduction: Perinatal hemolytic disease occurs due to the passage of antibodies from maternal to fetal circulation through the placenta; this leads to fetal erythrocytes hemolysis and death (in extreme cases). Regarding the treatment by intrauterine transfusion, little is known about the effect of the concentration of transfused adult red blood cells on the hemodynamics and gas exchanges in the fetal blood.

Objective: to compare the gasometric values between fetuses with gradual elevation of adult hemoglobin (HbA) concentration after intrauterine transfusion and anemic fetuses with only fetal hemoglobin (HbF).

Methods: a longitudinal observational study was carried out from 1998 to 2015 with 365 transfusions performed on 143 fetuses. The HbF concentration was determined by the Kleihauer-Betke test and pH, pCO2, pO2, SatO2, HCO3 and BE values were obtained from umbilical cord venous blood. The cases were ordered according to the deficit of Hb concentration in comparison with normality curve given for each gestational age.

Results: the gradual substitution of fetal by adult red blood cells did not significantly influenced the gasometric parameters for both Hb deficit lower than 5 g/dL [pH (p=0.958), pCO2 (p=0.400), pO2 (p=0.493), SatO2 (p=0.698), HCO3 (p=0.495) and BE (p=0.522)] and higher than 5 g/dL [pH (p=0.601), pCO2 (p=0.065), pO2 (p=0.770), SatO2 (p=0.096), HCO3 (p=0.096) and BE (p=0.525)].

Conclusions: Due to the existence of a hematological system with great capacity of metabolic balance, no associations between gasometric parameters and the percentage of HbF replacement were observed; this, regardless the degree of anemia resulted from Hb deficit

Keywords: Perinatal Hemolytic Disease; Maternal alloimmunization; Intrauterine transfusion; Fetal gasometry; Kleihauer; Fetal hemoglobin

Abstract| Introduction| Methods| Results| Discussion| Conclusion| References|