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ISSN: 2637-4544

Interventions in Gynaecology and Women's Healthcare

Research Article(ISSN: 2637-4544)

Chlorhexidine Alcohol Versus Povidone Iodine Prior to Elective Cesarean Section: A Randomized Open Label Controlled Trial

Volume 3 - Issue 3

Nisreen Aref Albezrah*

  • Author Information Open or Close
    • Head of Obstetric and Gynecology Department, Taif University, Saudi Arabia

    *Corresponding author:Nisreen Aref Albezrah, Head of Obstetric and Gynecology Department, Taif University, Saudi Arabia

Received:July 08, 2019;   Published: July 12, 2019

DOI: 10.32474/IGWHC.2018.03.000163

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Objective: To compare the incidence of SSI(surgicl site infection) betweenanti-sepsis solutions Chlorhexidine-Alcohol (CA) and Povidone-Iodine (PI) before elective CS(cesarean section).

Methods: Aprospective randomised controlled trial was conducted from January 2018 tell February, 2019 at the Obstetrics and Gynecology department of King Abd AL-Aziz Hospital, Saudi Arabia. Pregnant women greater than 18 years andreached 37 week of gestation andwere scheduled for elective cesarean delivery wererecruitmed. These womenwere randomly allocated in the ratio of 1:1 and received skin anti-septic preparation A (Chlorhexidine-Gluconate) or B (Povidone-Iodine). The primary outcome was superficial or deep SSI within 30 days after elective CS while the secondary outcomes assessed were hospital length of stay, readmission, endometritis and adverse skin reactions.

Results: There were 490 pregnant women indicated for elective CS randomized to CA group, while 493 to PI group. Significant difference was observed in SSI betweenCA and PI group (4.3% vs. 7.7%; p-value = 0.014). Moreover, difference was also significant in superficial SSI between the two groups (2.9% vs. 5.9%; p-value = 0.030). However, significant difference was not observed for deep SSI between the two groups (1.4% vs. 2.4%; p-value = 0.362). Among the secondary outcomes, significant difference was observed in the mean hospital stay (4.89 vs. 5.67; p-value = 0.001), while no significant difference was observed in hospital readmission and endometritis between the two groups. In conclusionChlorhexidine-Alcohol for pre-operative skin anti-sepsis in elective CS was associated with significantly lower risk SSI when compared to Povidone-Iodinesolution.

Keywords:Cesarean section; Surgical site infection; Chlorhexidine-Alcohol; Povidone-Iodine

Abstract| Introduction| Methods| Results| Discussion| References|