Genetic Polymorphisms at 17 Y-STR loci in Uzbek
Population
Volume 1 - Issue 5
Kurganov Sardarkhodja*, Axmedova Dilobar, Filatova Viktoriya Muxamedov Rustam and Axmedov Baxodir
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- Republican Centre of Forensic Expertise, Uzbekistan
*Corresponding author:
KurganovSardarkhodja, Republican Centre of Forensic Expertise29, Tashkent, Republic of Uzbekistan
Received: July 05, 2018; Published: July 12, 2018
DOI: 10.32474/PRJFGS.2018.01.000122
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Abstract
Haplotypes and allele frequencies for the 17 Y-chromosomal short tandem repeat (Y-STR) loci, DYS456, DYS389I, DYS390,
DYS389II, DYS458, DYS19, DYS385a/b, DYS393, DYS391, DYS439, DYS635, DYS392, Y GATA H4, DYS437, DYS438 and DYS448 were
determined in a sample of 1000 unrelated Uzbekistan males living in the regions of Tashkent (100), Fergana (75), Andijan (85),
Namangan (55), Sirdarya (55), Djizax (80),Samarqand (80), Kashqadarya (75), Surxandarya (50), Buxara (100), Navoiy (50), Xorezm
(97) and from Republic Karakalpakistan (98) using the Y-filer PCR Amplification Kit (Thermo Fisher Scientific).This population was
demonstrated 1000 haplotypes, of which 899 were unique. The gene diversity was 0.9988 (standard error:0.005).The haplotype
diversity calculated from the 17 Y-STR loci was 0.9967 and the discrimination capacity was 0.8990. The DYS385 locus showed the
highest gene diversity value (0.8936), while the DYS391 locus showed the lowest gene diversity value (0.4934).
Keywords: DNA analysis; Mutation; Y chromosome; Population data
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