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ISSN: 2637-4706

Drug Designing & Intellectual Properties International Journal

Research Article(ISSN: 2637-4706)

Synthesis and Antibacterial Evaluation of Some New Pyrimidine, Pyridine and Thiophene Derivatives Volume 3 - Issue 5

Abdel Haleem M Hussein*, Abu-Bakr AM El-Adasy, Ahmed AM El-Shareef, and Ahmed A Khames

  • Department of Chemistry, Faculty of Science, Al-Azhar University, Egypt

Received: March 13, 2021;   Published: March 23, 2021

Corresponding author: Abdel Haleem M. Hussein. Department of Chemistry, Faculty of Science, Al-Azhar University, Egypt

DOI: 10.32474/DDIPIJ.2021.03.000177

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New series of pyrimidine, pyridine and thiophene derivatives were prepared by reaction of appropriate 3-oxobutanamides with urea, thiourea, active methylene compounds, arylidines, salicyaldehyde, chalcones, benzyl isothiocyanate and aminopyrazoles. Compounds 2a, 3a, 3c and 9 show activity against some bacterial species, whereas, no activity was observed for compounds 3b, 4, 5, 7e, 7f, 10 and 11 against all bacterial species (Graphical Abstract).

Figure 1: Graphical Abstract.


Keywords: p-Aminobenzoic acid; 3-oxobutanamides; pyrimidines; pyridines; Thiophenes; antimicrobial activity

Abstract| Introduction| Results and Discussion| Antibacterial activity| Conclusion| Experimental| References|