Preparation of Polyelectrolyte Hydrogels and Study Their Controlled Release of Gabapentin

Volume 1 - Issue 2

Zaid A Abdulmonaim and Athir M Haddad*

Received: March 25, 2018;   Published: April 04, 2018

DOI: 10.32474/DDIPIJ.2018.01.000108

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Abstract

The semi interpenetrating network hydrogels (Z1-Z15) were prepared from different ratio of sodium alginate and linear poly (acrylamide-co-diallyl dimethyl ammonium chloride) then they mixed with the acrylamide and bisacrylamide as cross linking agent and polymerized via redox polymerization to form the semi-IPNs. All prepared semi-IPNs were loaded with three different amounts from Gabapentin as drug model. The swelling characteristics were studied for all semi- IPN hydrogels by determining the swelling ratio (Q).The release of Gabapentin was followed by using U.V. spectroscopy at (202 , 201 and 204) nm at constant temperature (37ºC) in distilled water , simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) respectly. The results of Gabapentin released indicated that all semi-IPNs have the ability to release drug to environment and the amount of Gabapentin released about 50% during two hours. Higuchi equation was used to determine the Higuchi constant which is very useful to forecasting the amount of Gabapentin released theoretically.

Keywords: Polyelectrolyte; Polymer Drug Delivery; Gabapentin

Abbrevations: SGF: Simulated Gastric Fluid; SIF: Simulated Intestinal Fluid; TDDSs: Targets Drug Delivery Systems; CDDSs: Controlled Drug Delivery Systems; SGF: Systems In Simulated Stomach Fluid; SIF: The Simulated Intestinal Fluid; WU: Water Uptake

Abstract| Introduction| Experiments| Results and Discussion| Conclusion| References|