Preparation of Polyelectrolyte Hydrogels and
Study Their Controlled Release of Gabapentin
Volume 1 - Issue 2
Zaid A Abdulmonaim and Athir M Haddad*
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- Department of Chemistry, University of Basrah, Iraq
*Corresponding author:
Athir M Haddad, Professor of Polymer Chemistry, Iraq
Received: March 25, 2018; Published: April 04, 2018
DOI: 10.32474/DDIPIJ.2018.01.000108
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Abstract
The semi interpenetrating network hydrogels (Z1-Z15) were prepared from different ratio of sodium alginate and linear poly
(acrylamide-co-diallyl dimethyl ammonium chloride) then they mixed with the acrylamide and bisacrylamide as cross linking agent
and polymerized via redox polymerization to form the semi-IPNs. All prepared semi-IPNs were loaded with three different amounts
from Gabapentin as drug model. The swelling characteristics were studied for all semi- IPN hydrogels by determining the swelling
ratio (Q).The release of Gabapentin was followed by using U.V. spectroscopy at (202 , 201 and 204) nm at constant temperature
(37ÂșC) in distilled water , simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) respectly. The results of Gabapentin
released indicated that all semi-IPNs have the ability to release drug to environment and the amount of Gabapentin released about
50% during two hours. Higuchi equation was used to determine the Higuchi constant which is very useful to forecasting the amount
of Gabapentin released theoretically.
Keywords: Polyelectrolyte; Polymer Drug Delivery; Gabapentin
Abbrevations: SGF: Simulated Gastric Fluid; SIF: Simulated Intestinal Fluid; TDDSs: Targets Drug Delivery Systems; CDDSs:
Controlled Drug Delivery Systems; SGF: Systems In Simulated Stomach Fluid; SIF: The Simulated Intestinal Fluid; WU: Water Uptake
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