Current Challenges and Obstacles to Drug Development for Chagas Disease

Volume 2 - Issue 2

Cauê Benito Scarim* and Chung Man Chin

Received: August 29, 2018;   Published: September 04, 2018

DOI: 10.32474/DDIPIJ.2018.02.000134

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Abstract

Chagas disease is a protozoan infection which was first identified more than one hundred years ago. But even now, drugs to treat the latent and chronic phases of the disease are not available. The success of a drug design is highly dependent on activity and toxicity. In the case of Chagas disease, questions remain as to identifying the best treatment (mainly for the chronic phase), and how new drugs and drug combinations compare to current therapy. The principal priority of this mini-review is to report the enormous difficulty that pharmaceutical chemists encounter in the development of new drugs for neglected tropical infectious diseases, in this case Chagas disease.

Keywords: Drug Development; New Drugs; Chagas Disease; T. cruzi

Abstract| Introduction| Challenges and Obstacles in Research and Development of New Anti-Chagasic Drugs| Scientific Expectations| Conclusion| Acknowledgment| Refernces|