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ISSN: 2637-4706

Drug Designing & Intellectual Properties International Journal

Review Article(ISSN: 2637-4706)

Antioxidant Properties and Antibacterial Activities of Leptadenia Hastata Leaves Extracts on Staphylococcus Aureus

Volume 1 - Issue 5

Isaac John Umaru1,2*, Fasihuddin A Badruddin1 and Hauwa A Umaru3

  • Author Information Open or Close
    • 1Faculty of Resource Science and Technology Universiti Malaysia Sarawak, Malaysia
    • 2Department of Biochemistry, Federal University Wukari, Taraba State, Nigeria
    • 3Department of Biochemistry, Moddibo Adama University, Yola Adamawa State, Nigeria

    *Corresponding author: Isaac John Umaru, Medicinal Biochemistry Federal University, Wukari Taraba State, Malaysia

Received: June 10, 2018;   Published: June 18, 2018

DOI: 10.32474/DDIPIJ.2018.01.000122

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Leptadenia hastata extracts were evaluated for antibacterial activity and antioxidant properties. The leaf of the plant was extracted with n-hexane, dichloromethane, ethyl acetate, chloroform and methanol to give respective extracts. The Antibacterial activity against staphylococcus aureus, was determined by disc diffusion method. Antioxidant activity was assayed by the DPPH radical scavenging activity mechanism. The results showed that of n-hexane, ethyl acetate, dichloromethane, chloroform and methanol extracts of Leptadenia hastata, methanol extract and chloroform extracts displayed more activity with 1.10 ± 0.10ab and 0.97 ± 0.06ab than others at 25-1000ppm/desk of the extracts tested. The most antioxidant activities against DPPH were displayed by the hexane and methanol extracts of Leptadenia hastata leaf, exhibiting IC50 (63.44μg/mL) and IC50 (46.80μg/mL) respectively, followed by chloroform, dichloromethane and lastly ethyl acetate crude extract. The present results showed potential of the medicinal plant used by traditional herbal medical practitioners as natural anti-microbial, antioxidant and potentially antiinflammatory agents. The results confirm that Leptadenia hastata leaves extracts can be used as a source of drugs to fight infections caused by susceptible bacteria.

Keywords: Staphylococcus aureus; Leptadenia hastata; 2; 2-diphenyl-1-pycryl-hydrazyl

Abstract| Introduction| Material and Method| Results and Discussion| Conclusion| Acknowledgment| Refernces|