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ISSN: 2637-4706

Drug Designing & Intellectual Properties International Journal

Research Article(ISSN: 2637-4706)

Antimicrobial Activity of Selected Plant Extracts

Volume 3 - Issue 4


  • Author Information Open or Close
    • Faculty of Natural Sciences, University of Guyana

    *Corresponding author: Jagessar, Department of Chemistry, Faculty of Natural Sciences, University of Guyana

Received: April 25, 2020;   Published: May 11, 2020

DOI: 10.32474/DDIPIJ.2020.03.000166

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This paper survey the antimicrobial activity of selected plant extracts from the Guyanese flora. Those described here are the extracts of Artocarpusaltilis (breadfruit), Brassica rapaChinensis (pakchoi), Passifloraedulis (passion fruit) and leaves of Terminaliacatappa. These extracts were assayed via the disc diffusion assay at three different concentrations of 0.001g/ml, 0.05g/ml and 0.1g/ml. At 0.01g/ml, Brassica rapachinensis induces the higest AZOI of 106.9mm2 against S. aureus. A.altilis showed 0.0 AZOI against all pathogens. At 0.1g/ml, A. altilis showed highest AZOI of 89.2mm2. Zero AZOI was obtained against all pathogens, with exception S. aureus. The CH2Cl2 extract of A. altilis, showed the highest AZOI of 59.0mm2 against B.subtilis. For the ethanolic extract, Brassica rapachinensis at 0.01g/ml showed highest AZOI of 209.3mm2, whereas the ethanolic extract at 0.1g/ml showed the highest AZOI of 126.0mm2. Antimicrobial activity of the combined fruit extracts of Brassica rapachinensis and A. altilis revealed that at 0.01g/ml, there was an augmentation of antimicrobial activity for S. aureus (153.9mm2) and C. albicans (168.9mm2). For passion fruit, the highest AZOI of 153.9mm2 was observed against C. albicans (AZOI = 153.9mm2), whereas the lowest against K. pneumoniae (AZOI =15.9mm2). In all cases, antimicrobial potency was less than that of the reference compound. Also, small antimicrobial selectivity was observed. Antimicrobial activity of the aqueous extract of Terminaliacatappa, revealed that the highest AZOI of 254.71mm2 was induced against K. pneumoniae and least of 80.08mm2 against C. albicans. K. pneumoniae showing a selectivity factor of over C. albicans. The AZOI induced by the aqueous extracts were greater than the AZOI induced by reference compounds Ampicillin and Nystatin.

Keywords: Aqueous and Ethanolic extract; Passion fruit (Passifloraedulis); Asceptic conditions; Susceptible; Standard antibiotics; Selective antimicrobial activity; Transition metal salts; DZOI and AZO

Abstract| Introduction| Literature Review| Methodology| Results| Discussion| Conclusion| References|