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ISSN: 2637-4706

Drug Designing & Intellectual Properties International Journal

Research Article(ISSN: 2637-4706)

An Overview on Niosomes: A Drug Nanocarrier

Volume 1 - Issue 5

Mahmoud Kamal1, Mohamed Maher1, Amr Ibrahim1 and Dina Louis1,2*

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    • 1Faculty of Pharmacy and Drug Technology, Heliopolis University, Egypt
    • 2Pharmaceutics and Industrial Pharmacy Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt

    *Corresponding author: Dina Louis, Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Cairo University, Kasr Eleini Street, Cairo, Egypt

Received: July 04, 2018;   Published: July 11, 2018

DOI: 10.32474/DDIPIJ.2018.01.000125

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Niosome are non-ionic surfactant vesicles acquired on hydration of synthetic nonionic surfactants, with or without consolidation of cholesterol or their lipids. They are vesicular systems like liposome’s that can be utilized as transporters of amphiphilic and lipophilic medications. Niosomes are promising vehicle for drug delivery and being non-ionic; and Niosomes are biodegradable, biocompatible non immunogenic and show adaptability and flexibility in their structural characterization. Niosomes have been generally assessed for controlled discharge and targeted delivery for the treatment of tumor, viral infections and other microbial illnesses. Niosomes can entangle both hydrophilic and lipophilic medications and can prolong the circulation of the entrapped medication in body. Encapsulation of medication in vesicular system can be anticipated to delay the presence of medication in the systemic circulation and enhance penetration into target tissue, maybe decrease toxicity if specific take-up can be accomplished. This review focuses on components of niosomes, types, the advantages, preparation methods, factors affecting, characterizations, and applications of noisome.

Keywords: Niosomes; Non-Ionic Surfactants; Cholesterol; Charged Molecules; Types; Preparation Methods; Characterization; Advantages; Applications

Abstract| Introduction| Components of Niosomes| Structure of Niosomes| Types of Niosomes| Methods of Preparation| Separation of Un entrapped Drug| Characterization of Niosomes| Advantages of Niosomes| Marketed Products| Future Prospects| Conclusion| Refernces|