An in vivo study for the effect of Citrus reticulata (Rutaceae) fruit peels extracts on the onset of toxicity of Cerastes cerastes venom in Albino mice

Mohamed A Gbaj¹, Inass A Sadawe², Nisreen H Meiqal², Salah M Bensaber², Massaud Salem Maamar³, Anton Hermann⁴ and Abdul M Gbaj²*

Received: April 03, 2019;   Published: April 25, 2019

DOI: 10.32474/DDIPIJ.2018.03.000153

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Abstract

Venom of Cerastes cerastes has been extracted and its toxicity was investigated in the presence of aqueous and methanolic extracts of Citrus reticulata (Rutaceae) fruit peels. The decline in the mean survival time of the male albino swiss mice were used to deduce the venom property in the presence and absence of aqueous and methanolic extracts of Citrus reticulata (Rutaceae) fruit peels. The aqueous and methanolic extracts of Citrus reticulata (Rutaceae) fruit Peels significantly decrease the mean survival time compared to the venom alone. From these results it was evident that the toxicity of Cerastes cerastes venomis increased significantly in the presence of Citrus reticulata in a dose dependent manner

Keywords:Citrus reticulata; Cerastes cerastes; Venom; Toxicity

Abstract| Introduction| Materials and Methods| Results and discussion| Conclusion| Acknowledgement| References|