A Review on Biomedical Applications of Polymeric Nanoparticles

A Krishna Sailaja*

Received:September 22, 2018;   Published: October 03, 2018

DOI: 10.32474/DDIPIJ.2018.02.000140

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Abstract

Splendid achievements have been made in management of disease through invention of drugs over past decade. The present conventional drug delivery systems often have side-effects and complications due to their wide distribution throughout the body fluids. The localization of drug action in injured tissue is a promising way to solve this problem. The objective of drug targeting is to achieve a desired pharmacological response at a selected site without undesirable interaction at other sites. This is especially important in cancer chemotherapy and rheumatoid arthritis treatment. Recently invention of drugs has been generated by various drug delivery systems like microspheres, liposomes, noisomes, nanocapsules and nanoparticles. Among all colloidal drug carriers’ nanoparticles are gaining more popularity because of their stability, easy preparation, for achieving reduced toxicity, for increased drug efficacy & site targeted action. Nanoparticulation is a very useful strategy towards targeted drug delivery and also for enhancement of bioavailability of low soluble drugs. In this article nanoparticles preparation methods and their biomedical applications were discussed in detail.

Keywords: Nanoparticles; Polymeric Materials; Bottom Up Approach

Abstract| Introduction| Experimental Measurements| Discussion of Results and Calculations| Conclusion| Refernces|