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ISSN: 2644-1217

Open Access Journal of Complementary & Alternative Medicine

Review ArticleOpen Access

Oxalate Degrading Lactic Acid Bacteria in Prevention and Management of Kidney Stone Volume 3 - Issue 5

Deepti Suman1* and Sreeja V2

    1,2Dairy Microbiology Department, Kamdhenu University, Gujarat

Received: November 01, 2021   Published: November 24, 2021

*Corresponding author: Deepti Suman, Dairy Microbiology Department, SMC College of Dairy Science, Kamdhenu University, Gandhinagar, Gujarat

DOI: 10.32474/OAJCAM.2021.03.000172

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Abstract

Oxalate degrading lactic acid bacteria possessing oxc (Oxalyl-CoA decarboxylase) and frc (Formyl-CoA transferase) genes are now being explored for their application as ingredients for prevention and management of kidney stone. Kidney stones increase the risk of developing chronic kidney disease and is associated with dysbiosis of gut microbiota Vaziri et al. [1]. Probiotics enhances the gut barrier by increasing mucus integrity, epithelial tight junction (ETJ) and epithelial cells survival and also control the overgrowth of pathobionts by reduction of pH and production of antimicrobial peptides (AMPs). Probiotic bacteria belonging to Bifidobacterium and Lactobacillus have been studied for their potential capability of oxalate degradation potential and reported high and efficient degradation of intestinal oxalate and reduces the level of oxaluria in patients with calcium-oxalate kidney stone and mild hyperoxaluria. The key oxalate degrading genes Oxc and frc have been sequenced in Lactobacillus and Bifidobacterium spp. and these strains are commonly used in dairy for probiotic preparation and management of kidney stone and are generally recognised as safe for human consumption. It was demonstrated that oxalate degrading Lactobacillus and Bifidobacterium species possessing probiotic properties and could possibly be used in a prophylactic approach and natural way for prevention and management of kidney stone disease.

Keywords: Oxalate; Lactic acid bacteria; Probiotics; Lactobacilli and Bifidobactrium

Abstract| Introduction| Kidney Stone| Types of Kidney Stones| Sources of oxalate in human body| Conclusion| References |

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