Oxalate Degrading Lactic Acid Bacteria in Prevention and
Management of Kidney Stone
Volume 3 - Issue 5
Deepti Suman1* and Sreeja V2
1,2Dairy Microbiology Department, Kamdhenu University, Gujarat
Received: November 01, 2021 Published: November 24, 2021
*Corresponding author: Deepti Suman, Dairy Microbiology Department, SMC College of Dairy Science, Kamdhenu University,
Gandhinagar, Gujarat
DOI: 10.32474/OAJCAM.2021.03.000172
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Abstract
Oxalate degrading lactic acid bacteria possessing oxc (Oxalyl-CoA decarboxylase) and frc (Formyl-CoA transferase) genes are now
being explored for their application as ingredients for prevention and management of kidney stone. Kidney stones increase the risk
of developing chronic kidney disease and is associated with dysbiosis of gut microbiota Vaziri et al. [1]. Probiotics enhances the gut
barrier by increasing mucus integrity, epithelial tight junction (ETJ) and epithelial cells survival and also control the overgrowth of
pathobionts by reduction of pH and production of antimicrobial peptides (AMPs). Probiotic bacteria belonging to Bifidobacterium
and Lactobacillus have been studied for their potential capability of oxalate degradation potential and reported high and efficient
degradation of intestinal oxalate and reduces the level of oxaluria in patients with calcium-oxalate kidney stone and mild
hyperoxaluria. The key oxalate degrading genes Oxc and frc have been sequenced in Lactobacillus and Bifidobacterium spp. and
these strains are commonly used in dairy for probiotic preparation and management of kidney stone and are generally recognised
as safe for human consumption. It was demonstrated that oxalate degrading Lactobacillus and Bifidobacterium species possessing
probiotic properties and could possibly be used in a prophylactic approach and natural way for prevention and management of
kidney stone disease.
Keywords: Oxalate; Lactic acid bacteria; Probiotics; Lactobacilli and Bifidobactrium
Abstract|
Introduction|
Kidney Stone|
Types of Kidney Stones|
Sources of oxalate in human body|
Conclusion|
References |