Background: Chinese calligraphy handwriting (CCH) enhances one’s cognitive, emotional, and physiological functions. Its
applications have shown effective improvements in psychological, psychosomatic, behavioral, and clinical disorders, including
anxiety symptoms associated with neurosis, depression, schizophrenia, and cancers.
Objectives: We tested the effects of a combined CCH plus Venlafaxine training as a new treatment method, which involved the
use of anti-anxiety drugs together with CCH training for a new system of behavioral intervention.
Methods: 60 patients meeting the criterion of CCMD-3 for anxiety disorder were assigned randomly to the Exp Group (N-31) or
the Control Group (N-29) for an eight-week protocol. The Exp Group was given both Venlafaxine and the CCH training, whereas the
Control Group received only Venlafaxine. Effects were evaluated with the Hamilton Anxiety Scale (HAMA), Self-Rating Anxiety Scale
(SAS), and Clinical Global Impression Scale (CGI) before and after 2, 4, 8 weeks of treatment, respectively.
Results: The Total Scores of HAMA, SAS, CGI in the Exp Group showed significant improvements after 4 and 8-weeks of the
treatment (p<.05). All Pre-Post t-tests for the Exp Group in all three measures reached P<0.01 level, whereas those for the Control
Group reached P<0.05 level of significance, both after the 8th week. postt-tests after the 4th week showed P<0.05 for the Exp Group,
but not for the Control Group in any of the measures.
Conclusion: Treatment by CCH plus Venlafaxine resulted in better effects than using only Venlafaxine for anxiety disorders. The
combined drug and CCH intervention offers effective clinical outcomes