email   Email Us: info@lupinepublishers.com phone   Call Us: +1 (914) 407-6109   57 West 57th Street, 3rd floor, New York - NY 10019, USA

Lupine Publishers Group

Lupine Publishers

ISSN: 2690-5760

Journal of Clinical & Community Medicine

Review Article(ISSN: 2690-5760)

Clinical and Laboratory Predictors for Total Antibody Against SARS-Cov-2 Among Convalescent Plasma Donors Volume 3 - Issue 3

Khin Phyu Pyar1*, Kyaw Myo Tun2, Kyaw Wunna3, Soe Win Hlaing4, Hein Htet OO5, Aung Aung6, Zarni Htet Aung7, Nyan Lin Maung8, Thurein Win9, Aung Phyoe Kyaw10, Kyaw Zay Ya11,Htet Aung12, Myo Thant Kyaw13 and Zay Phyo Aung14

  • 1Professor and Head/Senior Consultant Physician, Department of Medicine/ Department of Nephrology, Defense Services Medical Academy, Defense Services General Hospital, Myanmar
  • 2Associate Professor, Preventive and Social Medicine Department, Defense Services Medical Academy, Myanmar
  • 3Consultant Microbiologist, Defense Services General Hospital, Myanmar
  • 4Senior Consultant Physician, Department of Medicine, Defense Services General Hospital, Myanmar
  • 5Consultant Hematologist, Military Hospital, Myanmar
  • 6Consultant Hematologist, Defense Services General Hospital, Myanmar
  • 7Consultant Physician, Department of Medicine, Military Hospital, Myanmar
  • 8Consultant Physician, Department of Medicine, Military Hospital, Myanmar
  • 9Assistant Lecturer / Oncologist, Department of Medicine, Defense Services Medical Academy, Myanmar
  • 10Assistant Lecturer /Consultant Physician, Department of Medicine, Defense Services Medical Academy, Myanmar
  • 11Assistant Lecturer/Hematologist, Department of Medicine, Defense Services Medical Academy, Myanmar
  • 12Department of Pathology, Defense Services General Hospital, Myanmar
  • 13Assistant Lecturer, Department of Medicine, Defense Services Medical Academy, Myanmar
  • 14Assistant Lecturer, Department of Medicine, Defense Services Medical Academy, Myanmar

Received:July 21, 2021   Published: August 05, 2021

Corresponding author:Khin Phyu Pyar, Professor and Head/Senior Consultant Physician, Department of Medicine/ Department of Nephrology, Defense Services Medical Academy, Defense Services General Hospital, Myanmar

DOI: 10.32474/JCCM.2021.03.000164

 

Abstract PDF

To view the Full Article   Peer-reviewed Article PDF

Abstract

Background: We studied clinical, laboratory parameters and total antibody against SARS-CoV-2 among COVID-19 convalescent plasma donors.

Methods: We analyzed 302 serum specimens from 1335 candidates recovered from confirmed COVID-19 infection. Their clinical characteristics: symptoms, age, sex, body mass index, blood group, blood pressure, glycaemic status and renal function were related with SARS-CoV-2 total antibody level; it was measured twice with 4 weeks apart with the use of E411 Fully Automated Immuno Analyzer.

Findings: There was no relation between SARS-CoV-2 total antibody level with symptoms, age, sex and blood group, high blood pressure and diabetes mellitus. The percentage distribution of high total antibody level was significantly higher in candidates with blood group “Non-O” group (77.9%) than blood group “O” group (22.1%). (p= 0.03) Adequate total antibody level was detected in 22.9% in underweight group, 28.7% in normal BMI group, 45.5% in overweight group and 50% in obese group. There was positive relationship between BMI and adequate total antibody level (p = <0.001). Mean antibody level of participants with raised serum creatinine was 16.82 ± 15.28 COI; it was nearly half of those with normal renal function (33.58 ± 32.6 COI). Antibody levels measured at 70 days (mean=87.27 ± 25.96 COI) was significantly higher than that of 42 days (mean= 56.19 ± 20.23 COI).

Conclusion: The best predictor for adequate total antibody against SARS-CoV-2 were those candidates with normal or high BMI status, “non-O” blood group and normal serum creatinine; the plasma should be collected at 70 days symptom onset after COVID-19 infection.

Abstract| Introduction| Research Procedure| Results| Discussion| Conclusion| Acknowledgements| Declaration of Conflict of Interest| Ethical Approval| Funding| References|

Close

Online Submission System

Drag and drop files here

or

Browse Files
( For multiple files submission, zip them in a single file to submit. For file zipping software Download )