Clinical and Laboratory Predictors for Total Antibody Against SARS-Cov-2 Among Convalescent Plasma Donors Volume 3 - Issue 3

Khin Phyu Pyar¹*, Kyaw Myo Tun², Kyaw Wunna³, Soe Win Hlaing⁴, Hein Htet OO⁵, Aung Aung⁶, Zarni Htet Aung⁷, Nyan Lin Maung⁸, Thurein Win⁹, Aung Phyoe Kyaw¹⁰, Kyaw Zay Ya¹¹,Htet Aung¹², Myo Thant Kyaw¹³ and Zay Phyo Aung¹⁴

• ¹Professor and Head/Senior Consultant Physician, Department of Medicine/ Department of Nephrology, Defense Services Medical Academy, Defense Services General Hospital, Myanmar
• ²Associate Professor, Preventive and Social Medicine Department, Defense Services Medical Academy, Myanmar
• ³Consultant Microbiologist, Defense Services General Hospital, Myanmar
• ⁴Senior Consultant Physician, Department of Medicine, Defense Services General Hospital, Myanmar
• ⁵Consultant Hematologist, Military Hospital, Myanmar
• ⁶Consultant Hematologist, Defense Services General Hospital, Myanmar
• ⁷Consultant Physician, Department of Medicine, Military Hospital, Myanmar
• ⁸Consultant Physician, Department of Medicine, Military Hospital, Myanmar
• ⁹Assistant Lecturer / Oncologist, Department of Medicine, Defense Services Medical Academy, Myanmar
• ¹⁰Assistant Lecturer /Consultant Physician, Department of Medicine, Defense Services Medical Academy, Myanmar
• ¹¹Assistant Lecturer/Hematologist, Department of Medicine, Defense Services Medical Academy, Myanmar
• ¹²Department of Pathology, Defense Services General Hospital, Myanmar
• ¹³Assistant Lecturer, Department of Medicine, Defense Services Medical Academy, Myanmar
• ¹⁴Assistant Lecturer, Department of Medicine, Defense Services Medical Academy, Myanmar

Received:July 21, 2021   Published: August 05, 2021

Corresponding author:Khin Phyu Pyar, Professor and Head/Senior Consultant Physician, Department of Medicine/ Department of Nephrology, Defense Services Medical Academy, Defense Services General Hospital, Myanmar

DOI: 10.32474/JCCM.2021.03.000164

 

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Abstract

Background: We studied clinical, laboratory parameters and total antibody against SARS-CoV-2 among COVID-19 convalescent plasma donors.

Methods: We analyzed 302 serum specimens from 1335 candidates recovered from confirmed COVID-19 infection. Their clinical characteristics: symptoms, age, sex, body mass index, blood group, blood pressure, glycaemic status and renal function were related with SARS-CoV-2 total antibody level; it was measured twice with 4 weeks apart with the use of E411 Fully Automated Immuno Analyzer.

Findings: There was no relation between SARS-CoV-2 total antibody level with symptoms, age, sex and blood group, high blood pressure and diabetes mellitus. The percentage distribution of high total antibody level was significantly higher in candidates with blood group “Non-O” group (77.9%) than blood group “O” group (22.1%). (p= 0.03) Adequate total antibody level was detected in 22.9% in underweight group, 28.7% in normal BMI group, 45.5% in overweight group and 50% in obese group. There was positive relationship between BMI and adequate total antibody level (p = <0.001). Mean antibody level of participants with raised serum creatinine was 16.82 ± 15.28 COI; it was nearly half of those with normal renal function (33.58 ± 32.6 COI). Antibody levels measured at 70 days (mean=87.27 ± 25.96 COI) was significantly higher than that of 42 days (mean= 56.19 ± 20.23 COI).

Conclusion: The best predictor for adequate total antibody against SARS-CoV-2 were those candidates with normal or high BMI status, “non-O” blood group and normal serum creatinine; the plasma should be collected at 70 days symptom onset after COVID-19 infection.

Abstract| Introduction| Research Procedure| Results| Discussion| Conclusion| Acknowledgements| Declaration of Conflict of Interest| Ethical Approval| Funding| References|