Rationale: Coronavirus disease is an important serious pandemic worldwide infection. Anticoagulants and antiplatelet
medication are essential drugs in the management of COVID-19 infection. Bleeding tendency is an anxious adverse effect for these
drugs in hepatic patients. Patient concerns: An elderly male COVID-19 cirrhotic patient presented to physician outpatient clinic with
bilateral peripheral pneumonia. Diagnosis: COVID-19 pneumonia in cirrhotic patient. Interventions: Electrocardiography, chest CT
scan, and oxygenation. Outcomes: Gradual dramatic clinical, electrocardiographic, and radiological improvement had happened.
Lessons: It denotes the role of the low dose of anticoagulants, the low dose of antiplatelets, steroids, and antimicrobial therapy in
the management of COVID-19 pneumonia with liver cirrhosis. Using the lowest doses of anticoagulants, and antiplatelet was the
choice to avoid bleeding tendency. The mild elevations in liver enzymes indication of mild hepatic injury. The fluctuations in the
synthetic function of the liver including; S. albumen, total bilirubin, prothrombin time, and INR was within normal.
Keywords:COVID-19; Coronavirus; Peripheral pneumonia; Cirrhosis; At home diverse management