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ISSN: 2637-4609
Research Article(ISSN: 2637-4609) 
Spectrum Subtraction Method for Simultaneous Determination of Paracetamol and Diclofenac sodium in their Combined Pharmaceutical Dosage Forms
Volume 4 - Issue 3Mahmoud M Sebaiy1* and Amr A Mattar1,2
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Mahmoud M Sebaiy, Medicinal Chemistry Department, Zagazig University, Egypt
Received: February 04, 2020; Published: February 18, 2020
DOI: 10.32474/AOICS.2020.04.000188
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A simple, specific, accurate and precise spectrophotometric method was settled for simultaneous determination of paracetamol and Diclofenac Sodium in their pure form and in their pharmaceutical formulation. Spectrum subtraction technique has been used in simultaneous determination of both drugs without prior separation. Spectrum subtraction method parameters were validated according to ICH guidelines in which accuracy, precision, repeatability and robustness were found in accepted limits. Advantages and disadvantages of spectrum subtraction technique were discussed and statistical comparison between the proposed method and the reference one was also performed.
Keywords: Spectrophotometric; Paracetamol; Diclofenac Sodium; Spectrum subtraction; ICH guidelines; Statistical comparison.
Abstract| Introduction| Experimental Apparatus| Materials and Reagents| Procedure| Results and discussion| Conclusion| References|
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