Preparation of Morphine Derivatives Using Ionic Liquids

Volume 3 - Issue 2

Sureshbabu Jayachandra, Madhuresh Kumar Sethi*, Sanjay Mahajan, Kunwar Sanjeev Singh, Bhairaiah Mara and Purbita Chakraborty

Received: May 25, 2018;   Published: June 11, 2018

DOI: 10.32474/AOICS.2018.03.000156

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Abstract

Dextromethorphan, an anti tussive drug belongs to the morphinan family, and is mostly available in the market as a combination therapy. Most of the reported preparation procedures involve the use of racemic starting materials that give lower yields. (S)- Octa base is one of the key starting raw materials used in our process and this easy, convenient and eco-friendly preparation (single step) is reported in this manuscript. This drug, Dextromethorphan is produced in large volumes annually (> 150 tons/year). Most reported synthetic procedures make use of huge amounts of volatile organic solvents which are hazardous for environment. This will be a major issue in the near future. To overcome this problem, we have tried using Ionic liquid as a solvent in the preparation and successfully arrived at best results, thereby decreasing the use of organic volatile solvents.

Keywords: Dextromethorphan, Morphine derivatives, Alkaloids, Formylation, Ionic liquid

Abstract| Introduction| Mechanism of Action| Experimental and Results| Discussion| Conclusion| Acknowledgement| References|