One Step Synthesis of Coumarinfrom Cinnamaldehyde via Cinnamic Acid Intermediate

Volume 2 - Issue 4

Made Sudarma*, Siti Laili Zarwati and Made G Darmayanti

Received: April 02, 2018;   Published: April 13, 2018

DOI: 10.32474/AOICS.2018.02.000144

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Abstract

The purpose of this study was to develop an efficient method for the synthesis of pharmacologically interesting coumarin (1-benzopyran-2-one) from readily accessed natural products, in particular cinnamaldehyde. One step methodology for the synthesis of coumarin has been developed from cinnamaldehyde. A coumarin was synthesized smoothly via addition of chloro sulfonic acid to cinnamaldehyde. All the products have been confirmed by Thin Layer Chromatography and Gas Chromatography Mass Spectromatry analysis data.

Keywords: One step synthesis; Coumarin; Cinnamaldehyde; Chlorosulfonic acid

Abstract| Introduction| Experimental Results and Discussion| Conclusion| Acknowledgement| References|