Improved Enantioselective Enzymatic Synthesis of
(S) - Pregabalin
Volume 1 - Issue 3
Suresh babu Jayachandra, Madhuresh Sethi*, Vipinkumar Kaushik, Vijayakrishna Ravi, Sanjay Mahajan, Mujahid
Sufi Ahmed, Bhairaiah Mara, Gurleen Kaur and Purbita Chakraborty
-
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- R & D, Mylan Laboratories Ltd, India
*Corresponding author:
Madhuresh Sethi, R & D, Mylan Laboratories Ltd, Plot No: 31, 32, 33 and 34 A ANRICH Industrial Estate,
Andhra Pradesh, India
Received: January 23, 2018; Published: February 15, 2018
DOI: 10.32474/AOICS.2018.01.000115
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Abstract
The manuscript aims to throw light on the route of synthesis of (3S)-3-(Amino methyl)-5-methylhexanoic acid: (PREGABALIN),
which is a cost effective and efficient route. Pregabalin is a drug that is used in the treatment of epilepsy, neuropathic pain, fibromyalgia,
and generalized anxiety disorder. This process of synthesis makes use of a liquid enzyme to avoid cost hike and improves the overall
chiral purity of the final product accompanied with improved higher yields and purity. The investigational studies performed in this
article will help improve the existing processes in certain aspects as discussed above.
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