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ISSN: 2637-4609

Archives of Organic and Inorganic Chemical Sciences

Research Article(ISSN: 2637-4609)

Improved Enantioselective Enzymatic Synthesis of (S) - Pregabalin

Volume 1 - Issue 3

Suresh babu Jayachandra, Madhuresh Sethi*, Vipinkumar Kaushik, Vijayakrishna Ravi, Sanjay Mahajan, Mujahid Sufi Ahmed, Bhairaiah Mara, Gurleen Kaur and Purbita Chakraborty

  • Author Information Open or Close
    • R & D, Mylan Laboratories Ltd, India

    *Corresponding author: Madhuresh Sethi, R & D, Mylan Laboratories Ltd, Plot No: 31, 32, 33 and 34 A ANRICH Industrial Estate, Andhra Pradesh, India

Received: January 23, 2018;   Published: February 15, 2018

DOI: 10.32474/AOICS.2018.01.000115

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The manuscript aims to throw light on the route of synthesis of (3S)-3-(Amino methyl)-5-methylhexanoic acid: (PREGABALIN), which is a cost effective and efficient route. Pregabalin is a drug that is used in the treatment of epilepsy, neuropathic pain, fibromyalgia, and generalized anxiety disorder. This process of synthesis makes use of a liquid enzyme to avoid cost hike and improves the overall chiral purity of the final product accompanied with improved higher yields and purity. The investigational studies performed in this article will help improve the existing processes in certain aspects as discussed above.

Abstract| Introduction| Material and Methods| Results and Discussion| Conclusion| Acknowledgement| References|