Camphor Sulfonic Acid Catalyzed Facile and Atom Economical Access to Highly Substituted Piperidines via One Pot Multi Component Reactions

Volume 1 - Issue 3

Mahendra Chaudhari, Jitendra Gujar, Vilas B Labade and Murlidhar Shingare*

Received: January 25, 2018;   Published: February 05, 2018

DOI: 10.32474/AOICS.2018.01.000113

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Abstract

A simple and efficient protocol has been developed for the synthesis of highly substituted Piperidines derivatives. This strategy demonstrated five component reactions of two equivalents of aldehydes, two equivalents of anilines and β-keto esters in ethanol using 10 mol% of camphor sulfonic acid at reflux. The significant features of the present protocol include excellent yield, shorter reaction time, and easy work up procedure, broad substrate scope, high atom economy and formation of C-C and C-N bond in a single step operation.

Keywords: Piperidines; Camphor sulfonic acid; Multi component reactions; High atom economy

Abstract| Introduction| Material and Methods| Results and Discussion| Conclusion| Acknowledgement| References|