Benzotriazole: A Versatile Synthetic Auxiliary
Volume 2 - Issue 1
Siva S Panda*
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- Department of Chemistry & Physics, Augusta University, USA
*Corresponding author:
Siva S Panda, Department of Chemistry & Physics, Augusta University, Augusta, GA 30912, USA
Received: March 01, 2018; Published: March 09, 2018
DOI: 10.32474/AOICS.2018.02.000129
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Abstract
Benzotriazole (BtH) is particularly versatile synthetic
auxiliary because of its attractive properties. Benzotriazole can be
easily inserted into molecules and equally can also act as a good
leaving group. This molecule is a weak acid (pKa 8.2) as well as
weak base (pKa < 0) and because of this acid-base property of
benzotriazole. This molecule also shows not only electron donating
but also electron attracting ability, which leads to various synthetic
applications. In 1980, benzotriazole was first reported as synthetic
auxiliary in organic chemistry [1]. Since then benzotriazole is used
in the construction of various monocyclic and bicyclic heterocyclic
compounds which are difficult to prepare by other methods [2-5].
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