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ISSN: 2638-5945

Open Access Journal of Oncology and Medicine

Review ArticleOpen Access

Somatic Mutations in Cancer-Free Individuals: A Liquid Biopsy Connection

Volume 1 - Issue 1

Andrew Ford, Charmaine Brown and Chen Hsiung Yeh*

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    • PhD Circulogene Theranostics, USA

    *Corresponding author: Chen Hsiung Yeh, PhD Circulogene Theranostics 3125 Independence Dr, Suite 301 Birmingham, AL 35209, USA

Received: December 19, 2017;   Published: January 18, 2018

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Somatic mutations have been perceived as the causal event in the origin of the vast majority of cancers. Advanced massively parallel, highthroughput DNA sequencing have enabled the comprehensive characterization of somatic mutations in a large number of tumor samples for precision and personalized therapy. Understanding how these observed genetic alterations give rise to specific cancer phenotypes represents an ultimate goal of cancer genomics. However, somatic mutations are also commonly found in healthy individuals, which interfere with the effectiveness for cancer diagnostics.

Keywords: Somatic mutation; Germline; Cell-free DNA; Liquid biopsy; Next-generation sequencing

Abbreviations: NGS: Next-Generation Sequencing ; cfDNA: Cell-free DNA; MAF: Mutant Allele Frequency

Abstract| Introduction| References|