Prognostic Value and Clinical Significance of Lncrna SNHG7 in Human Cancers: A Meta Analysis Volume 5 - Issue 1

Yulu Zhang^1,2, Gang Liu^1,3, Qing Deng^1,3, Cong Li^1,2 and Zhi Hua Li^1,3*

• ¹Department of Breast Surgery, Third Hospital of Nanchang, JiangXi Breast Specialist Hospital, Nanchang, People’s Republic of China
• ²Jiangxi Medical College of Nanchang University, Nanchang, People’s Republic of China
• ³Key Laboratory of Breast Diseases in Jiangxi Province, Nanchang, People’s Republic of China

Received: September 05, 2021   Published: September 24, 2021

Corresponding author: Zhi Hua Li, Department of breast, The Third Hospital of Nanchang City, Jiangxi Breast Specialist Hospital, Nanchang, Jiangxi 330009, China

DOI: 10.32474/OAJOM.2021.05.000201

 

Abstract PDF

To view the Full Article   Peer-reviewed Article PDF

Abstract

Background: SNHG7 is a newly identified lncRNA which can regulate tumour growth and metastasis.However, role of SNHG7 in the the prognosis of various cancers is unclear.The aim of this meta analysis is to summarize the published studies to confirm the roles in tumor prognosis and its clinical significance.
Methods: A literature search of online databases was performed in Pubmed,Web of science and Embase. Pooled HRs and the corresponding 95% CIs for OS ,as well as ORs and the corresponding 95% CIs for TNM stage, histological grade, tumor size, and lymph node metastasis were evaluated.
Results: A total of seventeen studies with 1215 patients were enrolled in the meta analysis.Our results showed that high SNHG7 expression level was associated with an unfavorable OS (HR=2.51, 95% CI: 2.08–3.04) for various tumors. In addition, it was found that increased SNHG7 expression was significantly associated with TNM stage (OR = 3.33; 95% CI:2.55–4.36), tumor size (OR = 2.16; 95% CI:1.61–2.9), lymph node metastasis (OR = 3.84; 95% CI: 2.63–5.6). Nevertheless, there was no significant correlation between High SNHG7 expression level and histological grade (OR=0.75;95% CI:0.51-1.09).
Discussions: High SNHG7 expression is predictive of poor OS, poor TNM stage, larger tumor size, and more lymph node metastasis, which suggests High SNHG7 expression could serve as a independent novel biomarker of poor prognosis in cancer. But, additional studies are needed to validate this observation.

Keywords: Lncrna SNHG7, Clinical Significance, Prognosis, Human Cancer

Abstract| Introduction| Materials and Methods| Results| Discussion| Acknowledgements| Disclosure Statement| References|