email   Email Us: phone   Call Us: +1 (914) 407-6109   57 West 57th Street, 3rd floor, New York - NY 10019, USA

Lupine Publishers Group

Lupine Publishers

ISSN: 2638-5945

Open Access Journal of Oncology and Medicine

Editorial(ISSN: 2638-5945)

What is beyond the Nivolumab Monotherapy approval for advanced Hepatocellular Carcinoma?

Volume 1 - Issue 2

Luis Mendoza*

  • Author Information Open or Close
    • Senior Medical Advisor, IQVA, Europe

    *Corresponding author: Luis Mendoza, Senior Medical Advisor Medical Strategy & Science, Oncology-Hematology, Therapeutic Science & Strategy Unit, IQVA

Received: March 21, 2018;   Published: March 26, 2018

DOI: 10.32474/OAJOM.2018.01.000109

Full Text PDF

To view the Full Article   Peer-reviewed Article PDF


With an estimated 500,000 new cases per year, hepatocellular carcinoma (HCC) represents the third leading cause of cancer death worldwide. The incidence is rising in the west, largely due to an increasing incidence of hepatitis C virus infection [1]. The majority of HCC patients are diagnosed with disease too advanced for curative treatment. Only liver resection and liver transplantation are considered curative, with poor efficiency of other modalities such as radiofrequency ablation (RFA) and transarterial chemoembolization (TACE), although this may provide a modest prolongation in survival; however, the relapse in the majority of these patients is inevitable [2]. An array of translational research and pilot clinical trials have revealed that adoptive immunotherapy’s are safe by patients with HCC, but they lack efficacy [3]. Now, we are in the new era of immunotherapy’s such as immune checkpoint inhibitors and CAR-T strategies, which would bring benefit to the HCC patients.

Abbrevations: Hepatocellular carcinoma; Immune checkpoint inhibitors; Nivolumab; FDA

Editorial| References|


Online Submission System

Drag and drop files here


Browse Files
( For multiple files submission, zip them in a single file to submit. For file zipping software Download )