Nutritional Genomics - An Overview of CRISPR/Cas9 Genome Editing System on Nutraceuticals Volume 2 - Issue 4

Milap Mistry^1,2, Aayushi Patel^1,2, Shrina Patel^1,2, Laura Branch¹, Shobha Potlakayala¹, and Sairam Rudrabhatla¹*

• ¹Penn State Harrisburg, Middletown, PA, United States of America
• ²Equal Contribution

Received:December 14, 2021;   Published:January 6, 2022

*Corresponding author: Sairam Rudrabhatla, Professor of Biology, Program Chair of Biology & Science, Penn State Harrisburg, Middletown, USA

DOI: 10.32474/CTBM.2021.02.000145

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Abstract

Nutraceuticals have gained popularity for supplemental health benefits and for the ability to complement pharmaceuticals to prevent, delay, and manage chronic disease. The development of nutraceuticals involves the use of genome editing technology such as the newly developed CRISPR/Cas9 system, a novel and powerful method to knock out, knock-in, upregulate, and downregulate genes, including genes that can improve the nutritional profile of a plant as well as increase the production of nutraceuticals. Nutraceuticals, such as those implicated in aging, life expectancy, and chronic diseases can now be developed using CRISPR/Cas9. Establishing a CRISPR-based system to develop nutraceuticals and improve human health will benefit society.

Keywords: CRISPR/Cas9; Genome Editing; Nutritional Genomics; Nutraceuticals

Abbreviations: CRISPR: Clustered Regularly Interspaced Short Palindromic Repeats; Cas: CRISPR-Associated Protein; crRNA: CRISPR RNA; tracrRNA: Trans-Activating CRISPR RNA gRNA: guide RNA; sgRNA: Single Guide RNA; FAO: United Nations Food and Agricultural Organization; WHO: World Health Organization; FDA: Food and Drug Administration; DSHEA: Dietary Supplement Health and Education Act; GMP: Good Manufacturing Process; USDA: United States Department of Agriculture; GMO: genetically modified organism; EPA: Environmental Protection Agency; CR: caloric restrictions; IGF1R: insulin-like growth factor 1 receptor

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