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ISSN: 2637-4579

Open Access Journal of Biomedical Engineering and Biosciences

Review Article(ISSN: 2637-4579)

Novel Techniques for Improving Anti-Cancer Efficacy via Synergistic Phototherapy

Volume 2 - Issue 1

Jui Teng Lin1*, Kuo Ti Chen2 and Hsia Wei Liu2,3

  • Author Information Open or Close
    • 1New Vision Inc Taipei, Taiwan
    • 2Graduate Institute of Applied Science and Engineering, Fu Jen Catholic University, Taiwan
    • 3Department of Life Science, Fu Jen Catholic University, Taiwan

    *Corresponding author: Jui-Teng Lin, New Vision Inc. Taipei, Taiwan

Received: March 16, 2018;   Published: March 26, 2018

DOI: 10.32474/OAJBEB.2018.02.000126

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Factors influencing the cancer therapy efficiency in both photothermal therapy (PTT) and photodynamic therapy (PDT) using nanogold particles and photosensitizers, respectively, are analyzed. In PTT, heat diffusion kinetics is used to calculate the temperature increase resulted from the nanogold absorption of light energy, whereas photochemical kinetics is used to find the efficacy of PDT, or the generation rate of reactive oxygen species. Efficacy of cancer therapy may be enhanced by combining PTT and PDT either activated by one light or two lights. For maximum PTT/PDT synergistic efficacy, the concentration of photosensitizers and nanogold required optimization, besides the wavelength of the light matching the absorption peak of PS and nanogold, and the sequential order of PTT and PDT process. External supply of either photosensitizers or oxygen concentration will significantly improve the anti-cancer efficacy via type-II PDT. Optimization is required for maximum synergic efficacy.

Keywords: Photothermal Therapy; Optimal; Synergistic effect; Modeling; Heat diffusion; Photochemical kinetics

Abbrevations: PTT: Photothermal Therapy; PDT: Photodynamic Therapy; IND: Investigational New Drug; NRI: Near-Infrared; GNR: Gold Nanorod; PS: Photosensitizers; MB: Methylene Blue

Abstract| Introduction| Methods and Discussions| Conclusion| Acknowledgment| References|