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ISSN: 2637-4579

Open Access Journal of Biomedical Engineering and Biosciences

Research Article(ISSN: 2637-4579)

Neutron Activation and X-Ray Fluorescent Analysis in Study of Association Between Age and Chemical Element Contents in Thyroid of Males

Volume 2 - Issue 4

Dr. Vladimir Zaichick1* and FRS Sofia Zaichick2

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    • 1PhD, DSc, CChem, Professor, Radionuclide Diagnostics Department, Medical Radiological Research Centre, Russia
    • 2MD, PhD Laboratory of Dr. Gabriela Caraveo Piso, Feinberg School of Medicine, Northwestern University, Chicago, USA

    *Corresponding author: Dr. Vladimir Zaichick, PhD, DSc, CChem, Professor, Radionuclide Diagnostics Department, Medical Radiological Research Centre, 249036 Kaluga Region, Russia

Received: July 02, 2018;   Published: July 09, 2018

DOI: 10.32474/OAJBEB.2018.02.000144

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Abstract

A prevalence of thyroid dysfunction is higher in the elderly as compared to the younger population. An excess or deficiency of chemical element contents in thyroid may play important role in goitro- and carcinogenesis of gland. The variation with age of the mass fraction of twenty chemical elements (Ag, Br, Ca, Cl, Co, Cr, Cu, Fe, Hg, I, K, Mg, Mn, Na, Rb, Sb, Sc, Se, Sr, and Zn) in intact (normal) thyroid of 72 males (mean age 37.8 years, range 2-80 years) was investigated by energy dispersive X-ray fluorescent analysis and instrumental neutron activation analysis with high resolution spectrometry of short- and long-lived radionuclides. This work revealed that there is a statistically significant increase in Ca, I, and Se mass fraction, as well as a decrease in K and Mn mass fraction in the normal thyroid of male during a lifespan. Moreover, a disturbance of intra-thyroidal chemical element relationships with increasing age was found. Therefore, a goitrogenic and carcinogenic effect of inadequate Ca, I, K, Mn, and Se level in the thyroid of old males and a harmful impact of disturbance in intra-thyroidal chemical element relationships with increasing age may be assumed.

Keywords:Lasers, Crosslink, Photodynamic Therapy, Tissue Engineering, Cancer Therapy, Ophthalmology

Abbreviations:ROS: Reactive Oxygen Species; CRM/SRM: Certified/Standard Reference Materials; PEDXRF: Energy Dispersive X-Ray Fluorescent Analysis; INAA-SLR: Instrumental Neutron Activation Analysis with High Resolution Spectrometry of Short-Lived Radionuclides; INAA-LLR: Instrumental Neutron Activation Analysis with High Resolution Spectrometry of Short- and Long-Lived Radionuclides

Abstract| Introduction| Material and Methodology| Results and Discussion| Conclusion| Acknowledgement| References|

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