Computational Analysis of Pharmacogenomic based Compatibility of Micro RNA in Regulatory Network of Psoriasis: A Bioinformatics approach to initiate the discovery of Systemic biomarkers to treat Psoriasis

Volume 1 - Issue 1

Harishchander Anandaram*

Received: January 16, 2018;   Published: January 31, 2018

Full Text PDF

To view the Full Article   Peer-reviewed Article PDF

Abstract

In the era of post genomics, performing a computational analysis to understand the pharmacogenomic based regulation of Psoriasis with respect to the principles of data mining and constructing a regulatory network with respect to the principles of systems biology and analyzing the network with respect to the principles of test statistic remains a challenging task to execute. The challenge was approached by identifying the associated genes of Psoriasis from PharmGkb and it was followed by identifying the associated regulators (MicroRNAs and Transcription Factors) from PharmacomiR/ RegNetworks. Finally the Compatibility of miRNA in regulatory networks was analyzed by the statistical measures of miRmap.

Abstract| Introduction| Material and Methods| Results & Discussion| Network Construction & Analysis (Cytohubba)| Conclusion| References|