A Computational Simulation of Bladder Cancer Growth
Volume 1 - Issue 5
Chia Jung Chan*1, Tin-Kan Hung2 and Chih-Han Chang11*
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- 1Department of Biomedical Engineering, National Cheng Kung University, Taiwan
- 2Department of Bioengineering, University of Pittsburgh, Pittsburgh, USA
*Corresponding author:
Chia-Jung Chang, Department of Biomedical Engineering, National Cheng Kung University, Tainan, ROC,
Taiwan
Received: March 12, 2018; Published: March 16, 2018
DOI: 10.32474/OAJBEB.2018.01.000121
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Abstract
A three-dimensional (3D) simulation is established for bladder cancer development. Distribution of cancer cells is obtained by
using a Monte Carlo procedure. The tumor blocks are meshed with uniform hexahedral microelements. Each element is assessed
on its cancer growth probability (CGPi) during a time interval. The CGPi value is related to the growth of tumors. In this study, the
exponential growth of tumors is considered. Factors associated with the immune system, medication, and other cell conditions were
not yet included. The 3D computational modeling is anticipated to develop patient-specific simulation towards clinical management.
Keywords: Biological modeling; Bladder cancer; Monte Carlo method; Simulation
Abbrevations: V: Tumor volume; SGR: Specific Growth Rate; DT:Tumor Volume Doubling Time; CGPi : Cancer growth Probability;
CAi : Cancer Attribute
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