Preparation And Evaluation Of Mefenamic Acid Nanoparticles By Continuous Addition Method Using Butanol As Desolvating Agent Volume 4 - Issue 4

Berov G Lyubomir*

• Engineer, Independent Innovative Ideas Researcher, Smolyan 4700, Bulgaria

Received:June 2, 2021;  Published: July 15, 2021

Corresponding author: Berov G Lyubomir, Engineer, Independent Innovative Ideas Researcher, Smolyan 4700, Bulgaria

DOI: 10.32474/GJAPM.2021.04.000192

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Abstract

The aim of the present investigation is to prepare mefenamic acid nanoparticles by desolvation technique using butanol as desolvating agent. To 1% aqueous solution of mefenamic acid the desolvating agent was added continuously at the rate of 1 ml per minutes till the solution become turbid. Then a cross linking agent was added and kept for stirring for a period of 8 hours. The obtained nanoparticles were evaluated for product yield, Drug content, entrapment efficiency and loading capacity. The SEM images clearly reveals that the particles were found to be spherical in shape. The product yield, drug content, entrapment efficiency and loading capacity was found to be 85.6%, 53.7%, 85.05% and 83.52% respectively.

Abstract| Introduction| Criteria For Ideal Polymeric Carriers For Nanoparticles And Nanoparticle Delivery System| Different Techniques For Preparation of Nanoparticles| Nanoparticle Preparation By Cross-Linking Of Amphiphilic Macro Molecules| Materials and Methodology| Determination of Article Size| Conclusion| References|