Synthesis and Anxiolytic Activity of 2-(Substituted)- 5-[(N-Benzotriazolomethyl)-1,3, 4-Thiadiazolyl]-4- Thiazolidinone

Volume 1 - Issue 1

V K Singh*¹, Peeyush Bharadwaj¹ and Poonam Rishishwar²

Received: March 20, 2018;   Published: March 26, 2018

DOI: 10.32474/DDIPIJ.2018.01.000104

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Abstract

1,2,3-Benzotriazole (BTA) is a heterocyclic compound with three nitrogen atoms. It is a polar and colourless compound which can be used for its great versatility. The enormous investigations on derivatives of benzotriazole reveal wide applicability of this molecule for tagging and delivering huge number of heterocyclic nuclei. In the present work synthesis of several derivatives of 2-(substituted)-5-[(n-benzotriazolomethyl)-1,3,4-thiadiazolyl]-4-thiazolidinone has been synthesized and are evaluated for their anxiolytic activity. The antianxiety activities of the synthesized derivatives were evaluated using EPM test and Bright and dark box test experimental models of anxiety. All results were expressed as mean± standard error mean (SEM) and analysed by one-way ANOVA. Post-hoc comparisons were performed by applying Dunnet’s test. P <0.05 was considered statistically significant

Keywords: Benzotriazole; Thiadiazole; Thiazolidinone; Anxiolytic Activity; Anxiety; Elevated Plus Maize; Bright and Dark Arena

Abbrevations: IP: Intraperitoneally; IAEC: Institutional Animal Ethics Committee; SEM: Standard Error Mean

Abstract| Introduction| Materials and Methods| Determination of Anxiolytic Activity| Evaluation of Antianxiety Activity| Results| Discussion| Conclusion| Acknowledgement| Ethical Approval| References|