Preparation and Evaluation of Micro
particulate Drug Delivery Systems of Gliclazide
Employing Starch Acetate
Volume 1 - Issue 1
P Veera LakshmiM1, KPR Chowdary2*, A Prameela Rani3 and VUM Prasad4
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- 1PhD Scholar, School of Pharmacy, JNTUK India
- 2Research Director, Vikas Institute of Pharmaceutical Sciences India
- 3University College of Pharmaceutical Sciences, ANU India
- 4Programme Director, School of Pharmacy, JNTUK India
*Corresponding author:
KPR Chowdary, Research Director, Vikas Institute of Pharmaceutical Sciences India
Received: March 11, 2018; Published: March 19, 2018
DOI: 10.32474/DDIPIJ.2018.01.000103
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Abstract
Recently much emphasis is being laid on the development of micro particulate DDS in preference to single unit systems because
of their potential benefits such as increased bioavailability, reduced risk of systemic toxicity, reduced risk of local irritation and
predictable gastric emptying. The objective of the present study is to prepare and evaluate micro particulate drug delivery systems
of Gliclazide using starch acetate, a new modified starch for oral controlled release. The starch acetate (DS 2.75) was freely soluble
in chloroform and insoluble in several aqueous fluids and organic solvents. Chloroform could be used as solvent for starch acetate
in the preparation of micro particles, microcapsules and in film coating Spherical starch acetate- Gliclazide micro particles could
be prepared by the emulsification-solvent evaporation method. The method is industrially feasible as it involves emulsification and
removal of the solvent, which can be controlled precisely. The emulsification solvent evaporation method was reproducible with
regard to size and size distribution of the micro particles. About 65-70% of micro particles in each batch were in the size range
35/50 mesh (398.5μm) Encapsulation efficiency was in the range 96.0-99.3 % in the preparation of micro particles.
Gliclazide release from the starch acetate micro particles was slow and spread over longer periods of time. The drug release
depended on the proportion of core: coat in the micro particles. A good linear relationship (R²=0.826) between percent coat and
release rate (ko) was observed. The relationship could be expressed by the linear equation, y=12.18-0.173x where x is percent
coat and y is release rate (ko). Gliclazide release from the starch acetate micro particles was by non fickian (anomalous) diffusion.
Formulation F2 prepared using a Core: coat ratio of 8:2 gave slow, controlled and complete release (100%) of Gliclazide over 12
hours. As such formulation F2 is considered as a promising micro particulate DDS for oral control release of Gliclazide over 12 hours
for b.i.d administration
Keywords: Multi particulate drug delivery systems; Starch acetate; Gliclazide; Oral controlled release
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