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ISSN: 2637-4706

Drug Designing & Intellectual Properties International Journal

Review Article(ISSN: 2637-4706)

Intrinsically Disordered Proteins (IDPs): Experimental and Computational Approaches in Drug Discovery

Volume 1 - Issue 5

Suresh Kumar*

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    • Department of Diagnostic and Allied Health Science, Faculty of Health and Life Sciences, Management & Science University, Malaysia

    *Corresponding author: Suresh Kumar, Department of Diagnostic and Allied Health Science, Faculty of Health and Life Sciences, Management & Science University, Shah Alam, Selangor, Darul Ehsan, Malaysia

Received: June 24, 2018;   Published: July 02, 2018

DOI: 10.32474/DDIPIJ.2018.01.000123

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Abstract

Intrinsically disordered proteins (IDPs) are proteins that usually do not adopt well-defined native structures when isolated in solution under physiological conditions. Numerous IDPs have close relationships with human diseases such as Parkinson disease, Alzheimer disease, diabetes, and so on. Recently IDPs are getting importance as desirable drug targets for major diseases. This review introduces IDP’s in drug discovery by experimental and by computational approach.

Keywords: Protein disorder; Intrinsically Disordered Proteins; Disprot

Abbreviations: IDPs: Intrinsically Disordered Proteins; CD: Circular Dichroism; SAXS: Small-Angle Scattering of X-rays; PTMs: Post Translational Modifications; IDRs: Intrinsically Disordered Regions; IDPs: Intrinsically Disordered Proteins; pE-DB: Protein Ensemble Database

Abstract| Introduction| Experimental Determination of Intrinsically Disordered Proteins| Biological Importance of Intrinsically Disordered Proteins| Intrinsically Disordered Proteins as Drug Targets| Computational Tools for IDP’s Drug Discovery Study| Refernces|

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