Identification of Sirtuin Drug Targets (Homosapiens) For Lung Cancer-Molecular Docking and ADME Analysis

Volume 3 - Issue 4

Sameer* and Sudhakar Malla

Received: April 25, 2020;   Published: May 20, 2020

DOI: 10.32474/DDIPIJ.2020.03.000168

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Abstract

The objective of this study was to investigate the specific drug targets (Sirtuin 1,2,3,4,5, and 6) for lung cancer employing molecular docking simulation and ADME analysis against Sinapaldehyde. The three-dimensional structure of the protein was retrieved from Protein Data Base and of the ligand from Pubchem database. Molecular docking simulation of the compounds was performed using Ligpep 2.3, Schrodinger Suite 2009. In the present study, drug likeness analysis was performed through Lipinski filter & Admesar analysis using Swissadme online server and none of the compounds breached Lipinski’s and ADME parameters, making them prominent agents for bio-activities. And the outcome represents the compounds (Sinapaldehyde) possibly serve as for the cure of lung cancer.

Keywords: Sirtuin; Sinapaldehyde; Molecular docking; Lipinski; ADME Analysis, Anti-cancer

Abstract| Introduction| Methodology| Results and Discussion| Conclusion| References|