Current Challenges and Obstacles to Drug
Development for Chagas Disease
Volume 2 - Issue 2
Cauê Benito Scarim* and Chung Man Chin
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- Department of Drugs and Medicines, São Paulo State University (UNESP), Brazil
*Corresponding author:
Cauê Benito Scarim, Department of Drugs and Medicines, São Paulo State University (UNESP), Brazil
Received: August 29, 2018; Published: September 04, 2018
DOI: 10.32474/DDIPIJ.2018.02.000134
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Abstract
Chagas disease is a protozoan infection which was first identified more than one hundred years ago. But even now, drugs to
treat the latent and chronic phases of the disease are not available. The success of a drug design is highly dependent on activity and
toxicity. In the case of Chagas disease, questions remain as to identifying the best treatment (mainly for the chronic phase), and how
new drugs and drug combinations compare to current therapy. The principal priority of this mini-review is to report the enormous
difficulty that pharmaceutical chemists encounter in the development of new drugs for neglected tropical infectious diseases, in this
case Chagas disease.
Keywords: Drug Development; New Drugs; Chagas Disease; T. cruzi
Abstract|
Introduction|
Challenges and Obstacles in Research and
Development of New Anti-Chagasic Drugs|
Scientific Expectations|
Conclusion|
Acknowledgment|
Refernces|