Antidiabetic Plant Extracts

Volume 3 - Issue 1

Jagessar RC*

Received: April 08, 2019;   Published: April 15, 2019

DOI: 10.32474/DDIPIJ.2018.03.000152

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Abstract

Diabetes mellitus is a chronic health problem with long term consequences that are potentially preventable. It is a heterogeneous group of disease, characterized by high blood glucose levels resulting from impaired insulin secretion, impaired insulin action, or both. There are several synthetic antidiabetic drugs. These include Insulin Secretagogues (Sulfonylureas), biguanides, Thiazolidinediones, α- Glucosidase, Glucagon. Although, antidiabetic agents such as insulin, biguanides, thiazolidinediones and α glucosidase inhibitors are available in Guyana to treat diabetes, a safe and effective treatment paradigm is yet to be achieved. This is due to that fact that these drugs fail to significantly reduce the course of diabetic complications and have limited use because of their undesirable pathological conditions and high secondary failure rates. Therefore, it is essential to discover more effective antidiabetic agents with few adverse effects, low costs and ease of accessibility. In recent years, there has been a resurgence of interest in medicinal plants for the treatment of diseases. A World Health Organization (WHO) study shows that 80% of the world’s population solely relies on medicinal plants for their primary health care needs. Medicinal plant extracts, having antidiabetic properties can be a useful source for the development of oral hypoglycemic agents in both animal models and human subjects. Over 350 plants are used in the treatment of diabetes mellitus, but only a small number of these plants had gained scientific and medical evaluation to assess their effectiveness and efficacy.

Keywords:Diabetes; Chronic; Synthetic antidiabetic drugs; World Health Organisation; WHO

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