Novel Techniques for Improving Anti-Cancer Efficacy via Synergistic Phototherapy

Volume 2 - Issue 1

Jui Teng Lin¹*, Kuo Ti Chen² and Hsia Wei Liu^2,3

Received: March 16, 2018;   Published: March 26, 2018

DOI: 10.32474/OAJBEB.2018.02.000126

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Abstract

Factors influencing the cancer therapy efficiency in both photothermal therapy (PTT) and photodynamic therapy (PDT) using nanogold particles and photosensitizers, respectively, are analyzed. In PTT, heat diffusion kinetics is used to calculate the temperature increase resulted from the nanogold absorption of light energy, whereas photochemical kinetics is used to find the efficacy of PDT, or the generation rate of reactive oxygen species. Efficacy of cancer therapy may be enhanced by combining PTT and PDT either activated by one light or two lights. For maximum PTT/PDT synergistic efficacy, the concentration of photosensitizers and nanogold required optimization, besides the wavelength of the light matching the absorption peak of PS and nanogold, and the sequential order of PTT and PDT process. External supply of either photosensitizers or oxygen concentration will significantly improve the anti-cancer efficacy via type-II PDT. Optimization is required for maximum synergic efficacy.

Keywords: Photothermal Therapy; Optimal; Synergistic effect; Modeling; Heat diffusion; Photochemical kinetics

Abbrevations: PTT: Photothermal Therapy; PDT: Photodynamic Therapy; IND: Investigational New Drug; NRI: Near-Infrared; GNR: Gold Nanorod; PS: Photosensitizers; MB: Methylene Blue

Abstract| Introduction| Methods and Discussions| Conclusion| Acknowledgment| References|