Analysis of Association Between Rs3200401 Long Non- Coding RNA MALAT1 Gene Polymorphism and Prostate Adenocarcinoma Development in Ukrainian Population

Volkogon Andrii¹*, Chumachenko Yaroslav², Harbuzova Viktoriia² and Ataman Alexander³

Received: May 10, 2019;   Published: May 20, 2019

DOI: 10.32474/JUNS.2019.01.000122

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Abstract

MALAT1 (metastatic associated lung adenocarcinoma transcript 1) is one of the most well-known and most conserved long non-coding RNA (lncRNA). This lncRNA is considered to be the biomarker of PC increased risk, and high expression of its gene correlates with the worst survival rate in patients with PC. Thus, the objective of current study is to analyze the possible link between rs3200401 locus of lncRNA MALAT1 gene and prostate adenocarcinoma (PA) development in Ukrainian population. Venous blood of 184 patients with PA and 66 men without cancer was used for case-control study. MALAT1 rs3200401 polymorphism genotyping was performed by real-time PCR method. The statistical analysis of obtained data was performed using SPSS 17.0. Our data showed that MALAT1 rs3200401 SNP was related to PA, regardless of adjustment for age, smoking status and body mass index. The risk of PA development was significantly lower in rs3200401T-alleles homozygote compared to C-allele carriers (OR = 0.164; P = 0.005) and C-allele homozygotes (OR = 0.170; Pa = 0.006). The presented work is the first study about the role of rs3200401 MALAT1 gene single nucleotide polymorphism in prostate cancer development. Obtained results suggested that MALAT1 rs3200401T-alleles can be the possible genetic risk factor for PA development in Ukrainian population.

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