Nevus lipomatosis superficialis is a rare skin lesion characterized by the ectopic dermal deposition of adipose tissue. While
benign, it typically presents in the second to third decade of life as regional discomfort. We present the case of multiple lesions
requiring serial surgical management.
Presentation of Case: The patient was a 22-year-old male who presented with multiple, soft, warty lesions histologically
consistent with nevus lipomatosis superficialis. He underwent excision of the largest mass and is undergoing multiple excisions for
Discussion: Nevus lipomatosis superficialis is a rare connective tissue hamartoma of unclear etiology and multiple clinical
subtypes. While management is typically surgical, efficacy of treatment options for multiple nearby lesions is not well characterized.
Conclusion: We review the literature for nevus lipomatosis superficialis and describe a case with multiple lesions of varying
chronicity. Treatment must be chosen to optimize wound healing and cosmetic outcomes.