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ISSN: 2643-6760

Surgery & Case Studies: Open Access Journal

Case report(ISSN: 2643-6760)

Midazolam-Induced Hyperactivity Treated with Flumazenil

Volume 4 - Issue 3

Potru S1, Joseph A2 and Rajendram R3,4

  • Author Information Open or Close
    • 1Jackson Memorial Hospital, University of Miami, USA
    • 2Department of Anaesthesia, Changi General Hospital, Singapore
    • 3Department of Medicine, King Abdulaziz Medical City, Saudi Arabia
    • 4Joint Appointment Assistant Professor of Medicine, College of Medicine, King Saud bin Abdulaziz University of Health Sciences, Saudi Arabia

    *Corresponding author: Rajkumar Rajendram AKC BSc (Hons) MBBS (Dist) MRCP (UK) EDIC FRCP Edin FRCP Lond, Department of Medicine, King Abdulaziz Medical City, Ministry of National Guard - Health Affairs, Riyadh, Saudi Arabia

Received:February 06, 2020   Published: February 18, 2020

DOI: 10.32474/SCSOAJ.2020.04.000190

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Abstract

Benzodiazepines are characteristically anxiolytic, amnestic, and sedative. However, paradoxical reactions may cause agitation or aggression. We report a case in which a postoperative paradoxical reaction to midazolam was successfully managed with flumazenil (a benzodiazepine-receptor antagonist). Whilst the aetiology of benzodiazepine-induced hyperactivity remains unclear, this report demonstrates that even small amounts of flumazenil is an effective treatment. Despite the risks associated with the use of flumazemil we recommend its use for both diagnostic and therapeutic purposes.

Keywords: Midazolam, Benzodiazipine, Flumazenil

Abstract| Introduction| Case Report| Discussion| References|

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