Midazolam-Induced Hyperactivity
Treated with Flumazenil

Potru S; Joseph A; Rajendram; Rajendram

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ISSN: 2643-6760

Surgery & Case Studies: Open Access Journal

Case report(ISSN: 2643-6760)

Midazolam-Induced Hyperactivity Treated with Flumazenil

Volume 4 - Issue 3

Potru S¹, Joseph A² and Rajendram R^3,4

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- ¹Jackson Memorial Hospital, University of Miami, USA
- ²Department of Anaesthesia, Changi General Hospital, Singapore
- ³Department of Medicine, King Abdulaziz Medical City, Saudi Arabia
- ⁴Joint Appointment Assistant Professor of Medicine, College of Medicine, King Saud bin Abdulaziz University of Health Sciences, Saudi Arabia
*Corresponding author: Rajkumar Rajendram AKC BSc (Hons) MBBS (Dist) MRCP (UK) EDIC FRCP Edin FRCP Lond, Department of Medicine, King Abdulaziz Medical City, Ministry of National Guard - Health Affairs, Riyadh, Saudi Arabia

Received:February 06, 2020 Published: February 18, 2020

DOI: 10.32474/SCSOAJ.2020.04.000190

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Abstract

Benzodiazepines are characteristically anxiolytic, amnestic, and sedative. However, paradoxical reactions may cause agitation or aggression. We report a case in which a postoperative paradoxical reaction to midazolam was successfully managed with flumazenil (a benzodiazepine-receptor antagonist). Whilst the aetiology of benzodiazepine-induced hyperactivity remains unclear, this report demonstrates that even small amounts of flumazenil is an effective treatment. Despite the risks associated with the use of flumazemil we recommend its use for both diagnostic and therapeutic purposes.

Keywords: Midazolam, Benzodiazipine, Flumazenil

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