Benzodiazepines are characteristically anxiolytic, amnestic, and sedative. However, paradoxical reactions may cause agitation
or aggression. We report a case in which a postoperative paradoxical reaction to midazolam was successfully managed with
flumazenil (a benzodiazepine-receptor antagonist). Whilst the aetiology of benzodiazepine-induced hyperactivity remains unclear,
this report demonstrates that even small amounts of flumazenil is an effective treatment. Despite the risks associated with the use
of flumazemil we recommend its use for both diagnostic and therapeutic purposes.