Trichofolliculoma is a rare adnexal tumor of unknown etiology, occurring mainly in adults. It presents clinically as a solitary
flesh-coloured papule or nodule, sitting on the face and scalp area, with rarely extra cephalic localizations. Histologically, the
characteristic finding of trichofolliculoma include a squamous epithelium lined keratin containing dermal cyst with radiating hair
follicles from the cyst wall. We present a case of an adult male with trichofolliculoma located on the eyebrow, that has been surgically
removed without reccurence.
Trichofolliculoma is a uncommon benign tumor, generally
considered to be a hamartoma with a follicular differentiation.
It mostly affects young people and has a predilection for the face
and scalp area, in which it presents as a single papule or nodule
with a central depression from which a tuft of thin and white hair
emerges. In this case, we report a classic case of trichofolliculoma
of the face in a young man
A 36-year-old patient, without any notable history, presented in
our dermatology department for a lesion that appeared more than
two years ago, located on the left eyebrow, without no associated
functional signs which, however, caused a rather marked aesthetic
discomfort.
Clinical examination showed a well-circumscribed, fleshcoloured
nodular lesion of 6mm, painless on palpation and with a
hole in the center from which emerges a tuft of thin and whitish hairs
(Figure 1). A complete excision of the lesion was performed with an
anatomopathological study revealing a well-limited nodular benign
tumour proliferation at the periphery, centred by an infundibular
invagination (Figure 2) on which immature follicular structures,
in the form of small nodules of basaloid cells lacking cytonuclear
atypia, are connected. The whole was covered with an acanthosic
epidermis surmounted by an orthokeratosis with the presence of
horny plugs (Figure 3). On the basis of this histological finding, the
diagnosis of a trichofolliculoma was confirmed and no recurrence
was noted during follow-up at five months.
Figure 1: Eyeborw flesh-coloured tumor with tuft of hair
emerging from central depression
Figure 2: Histological section of a primary follicle with
dilated pore.
Figure 3: Histological section showing several secondary
follicles.
Described in 1944 by Miescher, trichofolliculoma is a rare
benign adnexal tumor that grows at the expense of the hair follicle
[1]. It is also described as a hamartoma of hair differentiation,
which is easy to diagnose clinically due to its typical appearance.
Usually presented as a single painless, papular or nodular, fleshcolored
or pink, centered by a tuft of white hairs emerging from
a central opening, which may be absent in atypical forms. This
tumor frequently sits on the face with some atypical extra-facial
localizations on the abdomen or scalp [2]. For some authors, it
would be more of a follicular malformation than a tumor of the hair
follicle itself, which would occur spontaneously, although a notion
of prior trauma was reported in a few cases.
The differential diagnosis can be made with trichoepithelioma,
keratoacanthoma, syringoma, sebaceous hyperplasia or basal
cell carcinoma if there is no duct [3]. Histopathology shows a
characteristic tumor finding consisting of a dilated central follicle
corresponding to the primary follicle, lined with a thick wall into
which secondary follicles with a highly variable differentiation
[4], ranging from mature secondary follicles with hair to the
anagen stage, and from a hair papilla to very immature structures,
end in a thick wall [5]. Sometimes it may contain rudimentary
sebaceous structures on the seborrheic areas. A routine surgical
excision without margins remains the treatment of choice for
trichofolliculoma, if the patient is requesting it or to establish the
diagnosis in hairless forms [6].
Trichofolliculoma is a rare benign tumor with a good prognosis
belonging to the group of adnexal tumors. Generally of typical
clinical presentation, it should be evoked in front of any facial or
scalp lesion with an emerging tuft of hair in the center.
Sellheyer K, Nelson P, Kutzner H, Patel RM (2013) The immunohistochemical differential diagnosis of microcystic adnexal carcinoma, desmoplastic trichoepithelioma and morpheaform basal cell carcinoma using BerEP4 and stem cell markers. J Cutan Pathol 40: 363-370.
Misago N, Kimura T, Toda S, Mori T, Narisawa Y (2010) A revaluation of trichofolliculoma: the histopathological and immunohistoche-mical features. Am J Dermatopathol 32(1): 35-43.
Fabrea F, Canihacb M, Jouaryc T (2014) Trichofolliculome du cuir chevelu. Annales de dermatologie et de vénéréologie 141: 736-737.
Jegou-Penouil MH, Bourseau-Quetier C, Cajanus S, Rigon JL, Risbourg M, et al. (2015) Trichofolliculomes: retrospective review of 8 cases. Annals of Dermatology and Venereology 142(3): 183-188.