Sildenafil Citrate for Women
Volume 1 - Issue 5
Mohamed Nabih EL Gharib*
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- Department of Obstetrics & Gynecology, Tanta University, Egypt
*Corresponding author:
Mohamed Nabih EL-Gharib, Professor of Obstetrics & Gynecology, Faculty of Medicine, Tanta University,
Egypt
Received: October 03, 2018; Published: October 09, 2018
DOI: 10.32474/OAJRSD.2018.01.000124
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Abstract
Sildenafil citrate (SC) is a medicinal drug used to treat male
erectile dysfunction and pulmonary hypertension. Sildenafil is a
selective and potent competitive inhibitor of the cyclic guanosine
monophosphate (cGMP) -specific phosphodiesterase-type 5
(PDE-5) enzymes, which, by preventing the breakdown of cGMP,
potentiate the action of NO in tissues that contain PDE-5. Thus,
increasing vasodilatation and potentiating the effects of nitrous
oxide (NO) on the vascular smooth muscle [1-2]. SC increases
uterine blood flow and potentiates estrogen-induced vasodilatation
[3]. Sildenafil citrate is metabolized is in the liver by cytochrome
P450, the metabolites are: N-desmethylsildenafil (about 50%
potency for PDE5). The biological half-life is from 3 to 4 hours, it is
excreted in feces and in urine [4].
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