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ISSN: 2641-1644

Open Access Journal of Reproductive System and Sexual Disorders

Mini Review(ISSN: 2641-1644)

Selective Androgen Receptor Modulators (SARMs): A Mini-Review

Volume 1 - Issue 1

Michael AB Naafs*

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    • Department of Endocrinology, International Health Consultancy, Netherlands

    *Corresponding author: Michael AB Naafs, Dutch Internist Endocrinologist, Health Consultant at Naafs, International Health Consultancy, Rhodoslaan 20, 7577KN, Oldenzaal, The Netherlands

Received: January 18, 2018;   Published: January 23, 2018

DOI: 10.32474/OAJRSD.2018.01.000103

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Abstract

Selective Androgen Receptor Modulators (SARMs) were discovered in the late 1990’s.They may have an application in treatments of various diseases, including muscle wasting, cancer cachexia, breast cancer, osteoporosis, andropause and sarcopenia. In this minireview the development, pharmacodynamics, and the phase 1 and 2 trial results of the SARMs are discussed with a special emphasis on the illicit use of the SARMs.

Abstract| Introduction| Preclinical and early clinical trials with SARMs| Conclusion| References|

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