Selective Androgen Receptor Modulators
(SARMs): A Mini-Review
Volume 1 - Issue 1
Michael AB Naafs*
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- Department of Endocrinology, International Health Consultancy, Netherlands
*Corresponding author:
Michael AB Naafs, Dutch Internist Endocrinologist, Health Consultant at Naafs, International Health Consultancy,
Rhodoslaan 20, 7577KN, Oldenzaal, The Netherlands
Received: January 18, 2018; Published: January 23, 2018
DOI: 10.32474/OAJRSD.2018.01.000103
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Abstract
Selective Androgen Receptor Modulators (SARMs) were discovered in the late 1990’s.They may have an application in treatments
of various diseases, including muscle wasting, cancer cachexia, breast cancer, osteoporosis, andropause and sarcopenia. In this minireview
the development, pharmacodynamics, and the phase 1 and 2 trial results of the SARMs are discussed with a special emphasis
on the illicit use of the SARMs.
Abstract|
Introduction|
Preclinical and early clinical trials with SARMs|
Conclusion|
References|